Is etretinate dangerous in papillon-lefévre syndrome?

Antonella Tosti, Patrizia Manuzzi, Federico Bardazzi, Angela Costa

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


A 23-year-old girl affected by Papillon-Lefevre syndrome developed, during Etretinate therapy (1 mg/kg/day), two liver abscesses caused by pyogenic bacteria and a subphrenic abscess. The immunological effects of retinoids may precipitate severe infections in patients with Papillon-Lefevre syndrome, who probably have a basic, even though not always evident, defect of PMN chemotaxis.

Original languageEnglish (US)
Pages (from-to)148-150
Number of pages3
Issue number3
StatePublished - Jan 1 1988
Externally publishedYes


  • Etretinate
  • Liver abscesses
  • Papillon-Lefévre syndrome
  • Severe infections

ASJC Scopus subject areas

  • Dermatology


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