Is endothelial cell autocrine production of tumor necrosis factor a mediator of lipid-induced endothelial dysfunction?

Michal J Toborek, B. Hennig

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Injury or dysfunction of the vascular endothelium is one of the first events in the development of atherosclerosis. Individual lipids, e.g. fatty acids or lipoproteins, are among the most critical factors which may induce injury to the endothelium. Selected fatty acids, such as linoleic acid, can disrupt endothelial barrier function and increase the inflammatory response of the vascular endothelium. The mechanisms of these processes are not fully understood. It is hypothesized that selected fatty acids can mediate the autocrine production of tumor necrosis factor-α in endothelial cells. This will activate a variety of intracellular signaling pathways and further potentiate endothelial injury initially induced by fatty acids.

Original languageEnglish
Pages (from-to)377-382
Number of pages6
JournalMedical Hypotheses
Volume47
Issue number5
DOIs
StatePublished - Nov 1 1996
Externally publishedYes

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Fatty Acids
Endothelial Cells
Tumor Necrosis Factor-alpha
Lipids
Vascular Endothelium
Wounds and Injuries
Linoleic Acid
Lipoproteins
Endothelium
Atherosclerosis

ASJC Scopus subject areas

  • Developmental Biology
  • Medicine(all)
  • Drug Discovery

Cite this

Is endothelial cell autocrine production of tumor necrosis factor a mediator of lipid-induced endothelial dysfunction? / Toborek, Michal J; Hennig, B.

In: Medical Hypotheses, Vol. 47, No. 5, 01.11.1996, p. 377-382.

Research output: Contribution to journalArticle

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