Abstract
Hepatocellular carcinoma (HCC) is a worldwide problem of epidemic proportions, best treated in a multidisciplinary setting. Major advances have been made in all specialties that manage patients with HCC, with surgical options at one end of the spectrum and palliative chemotherapy on the other, and the vast majority of patients require the involvement and expertise of interventional oncology. Several ablative and transarterial technologies are currently available. Irreversible electroporation (IRE) is a new ablative technology that uses high-voltage, low-energy DC current to create nanopores in the cell membrane, disrupting the homeostasis mechanism and inducing cell death by initiating apoptosis. This article discusses the evolution of IRE as well as its safety and efficacy in the context of other ablative therapies in the treatment of hepatic malignancies.
| Original language | English |
|---|---|
| Pages (from-to) | 67-73 |
| Number of pages | 7 |
| Journal | Seminars in Interventional Radiology |
| Volume | 30 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 4 2013 |
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Keywords
- apoptosis
- hepatocellular carcinoma (HCC) ablation
- irreversible electroporation (IRE)
- NanoKnife
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine
Cite this
Irreversible electroporation of hepatic malignancy. / Narayanan, Govindarajan; Froud, Tatiana; Suthar, Rekhaben; Barbery, Katuska.
In: Seminars in Interventional Radiology, Vol. 30, No. 1, 04.03.2013, p. 67-73.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Irreversible electroporation of hepatic malignancy
AU - Narayanan, Govindarajan
AU - Froud, Tatiana
AU - Suthar, Rekhaben
AU - Barbery, Katuska
PY - 2013/3/4
Y1 - 2013/3/4
N2 - Hepatocellular carcinoma (HCC) is a worldwide problem of epidemic proportions, best treated in a multidisciplinary setting. Major advances have been made in all specialties that manage patients with HCC, with surgical options at one end of the spectrum and palliative chemotherapy on the other, and the vast majority of patients require the involvement and expertise of interventional oncology. Several ablative and transarterial technologies are currently available. Irreversible electroporation (IRE) is a new ablative technology that uses high-voltage, low-energy DC current to create nanopores in the cell membrane, disrupting the homeostasis mechanism and inducing cell death by initiating apoptosis. This article discusses the evolution of IRE as well as its safety and efficacy in the context of other ablative therapies in the treatment of hepatic malignancies.
AB - Hepatocellular carcinoma (HCC) is a worldwide problem of epidemic proportions, best treated in a multidisciplinary setting. Major advances have been made in all specialties that manage patients with HCC, with surgical options at one end of the spectrum and palliative chemotherapy on the other, and the vast majority of patients require the involvement and expertise of interventional oncology. Several ablative and transarterial technologies are currently available. Irreversible electroporation (IRE) is a new ablative technology that uses high-voltage, low-energy DC current to create nanopores in the cell membrane, disrupting the homeostasis mechanism and inducing cell death by initiating apoptosis. This article discusses the evolution of IRE as well as its safety and efficacy in the context of other ablative therapies in the treatment of hepatic malignancies.
KW - apoptosis
KW - hepatocellular carcinoma (HCC) ablation
KW - irreversible electroporation (IRE)
KW - NanoKnife
UR - http://www.scopus.com/inward/record.url?scp=84874392759&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874392759&partnerID=8YFLogxK
U2 - 10.1055/s-0033-1333655
DO - 10.1055/s-0033-1333655
M3 - Article
AN - SCOPUS:84874392759
VL - 30
SP - 67
EP - 73
JO - Seminars in Interventional Radiology
JF - Seminars in Interventional Radiology
SN - 0739-9529
IS - 1
ER -