Irreversible electroporation of hepatic malignancy

Govindarajan Narayanan, Tatiana Froud, Rekhaben Suthar, Katuska Barbery

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Hepatocellular carcinoma (HCC) is a worldwide problem of epidemic proportions, best treated in a multidisciplinary setting. Major advances have been made in all specialties that manage patients with HCC, with surgical options at one end of the spectrum and palliative chemotherapy on the other, and the vast majority of patients require the involvement and expertise of interventional oncology. Several ablative and transarterial technologies are currently available. Irreversible electroporation (IRE) is a new ablative technology that uses high-voltage, low-energy DC current to create nanopores in the cell membrane, disrupting the homeostasis mechanism and inducing cell death by initiating apoptosis. This article discusses the evolution of IRE as well as its safety and efficacy in the context of other ablative therapies in the treatment of hepatic malignancies.

Original languageEnglish
Pages (from-to)67-73
Number of pages7
JournalSeminars in Interventional Radiology
Volume30
Issue number1
DOIs
StatePublished - Mar 4 2013

Fingerprint

Electroporation
Hepatocellular Carcinoma
Nanopores
Technology
Liver
Neoplasms
Homeostasis
Cell Death
Cell Membrane
Apoptosis
Safety
Drug Therapy
Therapeutics

Keywords

  • apoptosis
  • hepatocellular carcinoma (HCC) ablation
  • irreversible electroporation (IRE)
  • NanoKnife

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Irreversible electroporation of hepatic malignancy. / Narayanan, Govindarajan; Froud, Tatiana; Suthar, Rekhaben; Barbery, Katuska.

In: Seminars in Interventional Radiology, Vol. 30, No. 1, 04.03.2013, p. 67-73.

Research output: Contribution to journalArticle

Narayanan, G, Froud, T, Suthar, R & Barbery, K 2013, 'Irreversible electroporation of hepatic malignancy', Seminars in Interventional Radiology, vol. 30, no. 1, pp. 67-73. https://doi.org/10.1055/s-0033-1333655
Narayanan, Govindarajan ; Froud, Tatiana ; Suthar, Rekhaben ; Barbery, Katuska. / Irreversible electroporation of hepatic malignancy. In: Seminars in Interventional Radiology. 2013 ; Vol. 30, No. 1. pp. 67-73.
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