TY - JOUR
T1 - Irreversible Electroporation of Hepatic and Pancreatic Malignancies
T2 - Radiologic-Pathologic Correlation
AU - Gonzalez-Beicos, Aldo
AU - Venkat, Shree
AU - Songrug, Tanakorn
AU - Poveda, Julio
AU - Garcia-Buitrago, Monica
AU - Poozhikunnath Mohan, Prasoon
AU - Narayanan, Govindarajan
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Irreversible electroporation (IRE) is a novel therapy that has shown to be a feasible and promising alternative to conventional ablative techniques when treating tumors near vital structures or blood vessels. The clinical efficacy of IRE has been evaluated using established imaging criteria. This study evaluates the histologic and imaging response of hepatic and pancreatic malignancies that were surgically resected after IRE. In total, 12 lesions ablated with IRE were included, including 3 pancreatic carcinomas, 5 primary tumors of the liver, and 4 metastatic tumors of the liver. The rate of complete response to IRE was 25% based on the histologic evaluation of the resected tumors. Although treatment-related vessel wall changes were noted in several cases in histologic findings, there was no evidence of vascular luminal narrowing or obliteration in any of the specimens. The imaging response to IRE before surgical resection usually resulted in underestimation of disease burden when compared with the histologic response seen on the resected specimens.
AB - Irreversible electroporation (IRE) is a novel therapy that has shown to be a feasible and promising alternative to conventional ablative techniques when treating tumors near vital structures or blood vessels. The clinical efficacy of IRE has been evaluated using established imaging criteria. This study evaluates the histologic and imaging response of hepatic and pancreatic malignancies that were surgically resected after IRE. In total, 12 lesions ablated with IRE were included, including 3 pancreatic carcinomas, 5 primary tumors of the liver, and 4 metastatic tumors of the liver. The rate of complete response to IRE was 25% based on the histologic evaluation of the resected tumors. Although treatment-related vessel wall changes were noted in several cases in histologic findings, there was no evidence of vascular luminal narrowing or obliteration in any of the specimens. The imaging response to IRE before surgical resection usually resulted in underestimation of disease burden when compared with the histologic response seen on the resected specimens.
KW - Hepatic malignancy
KW - Irreversible electroporation
KW - Pancreatic malignancy
UR - http://www.scopus.com/inward/record.url?scp=84941278176&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941278176&partnerID=8YFLogxK
U2 - 10.1053/j.tvir.2015.06.009
DO - 10.1053/j.tvir.2015.06.009
M3 - Article
C2 - 26365548
AN - SCOPUS:84941278176
VL - 18
SP - 176
EP - 182
JO - Techniques in Vascular and Interventional Radiology
JF - Techniques in Vascular and Interventional Radiology
SN - 1089-2516
IS - 3
ER -