Irreversible Electroporation of Hepatic and Pancreatic Malignancies: Radiologic-Pathologic Correlation

Aldo Gonzalez-Beicos, Shree Venkat, Tanakorn Songrug, Julio Poveda, Monica Garcia-Buitrago, Prasoon Poozhikunnath Mohan, Govindarajan Narayanan

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Irreversible electroporation (IRE) is a novel therapy that has shown to be a feasible and promising alternative to conventional ablative techniques when treating tumors near vital structures or blood vessels. The clinical efficacy of IRE has been evaluated using established imaging criteria. This study evaluates the histologic and imaging response of hepatic and pancreatic malignancies that were surgically resected after IRE. In total, 12 lesions ablated with IRE were included, including 3 pancreatic carcinomas, 5 primary tumors of the liver, and 4 metastatic tumors of the liver. The rate of complete response to IRE was 25% based on the histologic evaluation of the resected tumors. Although treatment-related vessel wall changes were noted in several cases in histologic findings, there was no evidence of vascular luminal narrowing or obliteration in any of the specimens. The imaging response to IRE before surgical resection usually resulted in underestimation of disease burden when compared with the histologic response seen on the resected specimens.

Original languageEnglish (US)
Pages (from-to)176-182
Number of pages7
JournalTechniques in Vascular and Interventional Radiology
Volume18
Issue number3
DOIs
StatePublished - Sep 1 2015

Keywords

  • Hepatic malignancy
  • Irreversible electroporation
  • Pancreatic malignancy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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