Irinotecan in the management of patients with pancreatic cancer

Mark R. Green, Melinda Harper, Ahmad Safa, Carol A. Sherman, Chaudry M. Mushtaq, Hamid Bahadori, Frank J. Brescia, Caio M S P Rocha Lima

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Synergy with no overlapping toxicities has been demonstrated for the combination of irinotecan (Camptosar, CPT-11) and gemcitabine (Gemzar) in vitro. Results of a single-institution phase I study in which patients with previously untreated pancreatic cancer were given irinotecan and gemcitabine were promising, with two of three patients achieving a partial response. Because of the favorable outcome of the phase I study, a multicenter phase II trial was undertaken in previously untreated patients with pancreatic carcinoma. Data from other sites entering patients in this phase II study have been analyzed, and a multicenter phase III trial of single-agent gemcitabine vs the irinotecan combination in first-line treatment of patients with locally advanced or metastatic pancreatic cancer is underway.

Original languageEnglish
Pages (from-to)31-33
Number of pages3
JournalOncology
Volume14
Issue number12 SUPPL. 14
StatePublished - Dec 1 2000

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irinotecan
gemcitabine
Pancreatic Neoplasms
Multicenter Studies

ASJC Scopus subject areas

  • Oncology

Cite this

Green, M. R., Harper, M., Safa, A., Sherman, C. A., Mushtaq, C. M., Bahadori, H., ... Rocha Lima, C. M. S. P. (2000). Irinotecan in the management of patients with pancreatic cancer. Oncology, 14(12 SUPPL. 14), 31-33.

Irinotecan in the management of patients with pancreatic cancer. / Green, Mark R.; Harper, Melinda; Safa, Ahmad; Sherman, Carol A.; Mushtaq, Chaudry M.; Bahadori, Hamid; Brescia, Frank J.; Rocha Lima, Caio M S P.

In: Oncology, Vol. 14, No. 12 SUPPL. 14, 01.12.2000, p. 31-33.

Research output: Contribution to journalArticle

Green, MR, Harper, M, Safa, A, Sherman, CA, Mushtaq, CM, Bahadori, H, Brescia, FJ & Rocha Lima, CMSP 2000, 'Irinotecan in the management of patients with pancreatic cancer', Oncology, vol. 14, no. 12 SUPPL. 14, pp. 31-33.
Green MR, Harper M, Safa A, Sherman CA, Mushtaq CM, Bahadori H et al. Irinotecan in the management of patients with pancreatic cancer. Oncology. 2000 Dec 1;14(12 SUPPL. 14):31-33.
Green, Mark R. ; Harper, Melinda ; Safa, Ahmad ; Sherman, Carol A. ; Mushtaq, Chaudry M. ; Bahadori, Hamid ; Brescia, Frank J. ; Rocha Lima, Caio M S P. / Irinotecan in the management of patients with pancreatic cancer. In: Oncology. 2000 ; Vol. 14, No. 12 SUPPL. 14. pp. 31-33.
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