Purpose. The rabbit is often used as a model for testing novel glaucoma treatments, surgical procedures and implants with IOP readings used as the criteria in determining efficacy. As IOP redings are usually taken with the animal under anesthesia, we assessed the IOP in function of anesthesia time by sequential measurements. Methods. Goldmann applanation IOP readings were taken before and 5 min. after intramuscular injection of Ketamine hydrochloride (14mg/kg) and Xylazine hydrochloride (7mg/kg) on 8 rabbits and repeated every 2.5 min. thereafter for 1 hr. Results. IOP dropped by 13.4±18% at 5 min. after injection, 40.8±24% at 10 min., 51.0±21% at 15 min. and was ≈ stable from 20 to ≈ 40 min. Conclusion. The IOP changes too drastically during the first 10 min. after injection of the anesthetic and more accurate data can be obtained with IOP readings taken 15 min. after injection and by comparing the treated with the un-treated contralateral eye as a criteria for efficacy of novel glaucoma treatments, procedures and implants.
|Original language||English (US)|
|Journal||Investigative Ophthalmology and Visual Science|
|State||Published - Feb 15 1996|
ASJC Scopus subject areas
- Sensory Systems
- Cellular and Molecular Neuroscience