Ionic mechanisms in pancreatic β cell signaling

Shao Nian Yang, Yue Shi, Guang Yang, Yuxin Li, Jia Yu, Per Olof Berggren

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The function and survival of pancreatic β cells critically rely on complex electrical signaling systems composed of a series of ionic events, namely fluxes of K(+), Na(+), Ca(2+) and Cl(-) across the β cell membranes. These electrical signaling systems not only sense events occurring in the extracellular space and intracellular milieu of pancreatic islet cells, but also control different β cell activities, most notably glucose-stimulated insulin secretion. Three major ion fluxes including K(+) efflux through ATP-sensitive K(+) (KATP) channels, the voltage-gated Ca(2+) (CaV) channel-mediated Ca(2+) influx and K(+) efflux through voltage-gated K(+) (KV) channels operate in the β cell. These ion fluxes set the resting membrane potential and the shape, rate and pattern of firing of action potentials under different metabolic conditions. The KATP channel-mediated K(+) efflux determines the resting membrane potential and keeps the excitability of the β cell at low levels. Ca(2+) influx through CaV1 channels, a major type of β cell CaV channels, causes the upstroke or depolarization phase of the action potential and regulates a wide range of β cell functions including the most elementary β cell function, insulin secretion. K(+) efflux mediated by KV2.1 delayed rectifier K(+) channels, a predominant form of β cell KV channels, brings about the downstroke or repolarization phase of the action potential, which acts as a brake for insulin secretion owing to shutting down the CaV channel-mediated Ca(2+) entry. These three ion channel-mediated ion fluxes are the most important ionic events in β cell signaling. This review concisely discusses various ionic mechanisms in β cell signaling and highlights KATP channel-, CaV1 channel- and KV2.1 channel-mediated ion fluxes.

Original languageEnglish
Pages (from-to)4149-4177
Number of pages29
JournalCellular and molecular life sciences : CMLS
Volume71
Issue number21
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

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Cell signaling
KATP Channels
Fluxes
Ions
Insulin
Action Potentials
Voltage-Gated Potassium Channels
Membranes
Islets of Langerhans
Ion Channels
Depolarization
Electric potential
Cell membranes
Membrane Potentials
Brakes
Adenosine Triphosphate
Cells
Glucose
Extracellular Space
Cell Survival

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Yang, S. N., Shi, Y., Yang, G., Li, Y., Yu, J., & Berggren, P. O. (2014). Ionic mechanisms in pancreatic β cell signaling. Cellular and molecular life sciences : CMLS, 71(21), 4149-4177. https://doi.org/10.1007/s00018-014-1680-6

Ionic mechanisms in pancreatic β cell signaling. / Yang, Shao Nian; Shi, Yue; Yang, Guang; Li, Yuxin; Yu, Jia; Berggren, Per Olof.

In: Cellular and molecular life sciences : CMLS, Vol. 71, No. 21, 01.11.2014, p. 4149-4177.

Research output: Contribution to journalArticle

Yang, SN, Shi, Y, Yang, G, Li, Y, Yu, J & Berggren, PO 2014, 'Ionic mechanisms in pancreatic β cell signaling', Cellular and molecular life sciences : CMLS, vol. 71, no. 21, pp. 4149-4177. https://doi.org/10.1007/s00018-014-1680-6
Yang, Shao Nian ; Shi, Yue ; Yang, Guang ; Li, Yuxin ; Yu, Jia ; Berggren, Per Olof. / Ionic mechanisms in pancreatic β cell signaling. In: Cellular and molecular life sciences : CMLS. 2014 ; Vol. 71, No. 21. pp. 4149-4177.
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