Ion-selective microelectrodes suitable for recording rapid changes in extracellular ion concentration

Rong Wen; Burks Oakley

doi:10.1016/0165-0270(90)90112-S

Ion-selective microelectrodes suitable for recording rapid changes in extracellular ion concentration

Rong Wen, Burks Oakley

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A method for fabricating double-barrel, ion-selective microelectrodes with fine tips (0.5-1.5 μm) and rapid response times is described. When made into K⁺-selective microelectrodes, the electrodes respond to changes in [K⁺]_o with a time constant of 70-95 ms. The electrical response of these electrodes to common-mode voltages can be made to have a time constant of < 2 ms, which minimizes electrical artifacts from field potentials. The application of these microelectrodes to the measurement of rapid, transient changes in retinal [K⁺]_o is presented.

Original language	English (US)
Pages (from-to)	207-213
Number of pages	7
Journal	Journal of Neuroscience Methods
Volume	31
Issue number	3
DOIs	https://doi.org/10.1016/0165-0270(90)90112-S
State	Published - Mar 1990
Externally published	Yes

Keywords

Electroretinogram b-wave
Extracellular potassium
K-selective microelectrode
Vertebrate retina

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0165-0270(90)90112-S

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Cite this

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title = "Ion-selective microelectrodes suitable for recording rapid changes in extracellular ion concentration",

abstract = "A method for fabricating double-barrel, ion-selective microelectrodes with fine tips (0.5-1.5 μm) and rapid response times is described. When made into K+-selective microelectrodes, the electrodes respond to changes in [K+]o with a time constant of 70-95 ms. The electrical response of these electrodes to common-mode voltages can be made to have a time constant of < 2 ms, which minimizes electrical artifacts from field potentials. The application of these microelectrodes to the measurement of rapid, transient changes in retinal [K+]o is presented.",

keywords = "Electroretinogram b-wave, Extracellular potassium, K-selective microelectrode, Vertebrate retina",

author = "Rong Wen and Burks Oakley",

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language = "English (US)",

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AU - Wen, Rong

AU - Oakley, Burks

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N2 - A method for fabricating double-barrel, ion-selective microelectrodes with fine tips (0.5-1.5 μm) and rapid response times is described. When made into K+-selective microelectrodes, the electrodes respond to changes in [K+]o with a time constant of 70-95 ms. The electrical response of these electrodes to common-mode voltages can be made to have a time constant of < 2 ms, which minimizes electrical artifacts from field potentials. The application of these microelectrodes to the measurement of rapid, transient changes in retinal [K+]o is presented.

AB - A method for fabricating double-barrel, ion-selective microelectrodes with fine tips (0.5-1.5 μm) and rapid response times is described. When made into K+-selective microelectrodes, the electrodes respond to changes in [K+]o with a time constant of 70-95 ms. The electrical response of these electrodes to common-mode voltages can be made to have a time constant of < 2 ms, which minimizes electrical artifacts from field potentials. The application of these microelectrodes to the measurement of rapid, transient changes in retinal [K+]o is presented.

KW - Electroretinogram b-wave

KW - Extracellular potassium

KW - K-selective microelectrode

KW - Vertebrate retina

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