Ion movements during energy-linked mitochondrial structural changes

Keith A Webster, J. R. Bronk

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The structure of isolated rat liver mitochondria has been observed in the electron microscope following incubation of the mitochondria in vitro under a variety of conditions. The results show that ultrastructural changes are only associated with the energization and deenergization of isolated mitochondria if the composition of the incubation medium permits ion movements in or out of the matrix. The mechanism of energy coupling does not appear to depend on these major mitochondrial structural changes. The addition of low levels of valinomycin greatly increases the rate at which the matrix compartment swells and shrinks on energization and deenergization even at low K+ concentrations.

Original languageEnglish
Pages (from-to)23-44
Number of pages22
JournalJournal of Bioenergetics and Biomembranes
Volume10
Issue number1-2
DOIs
StatePublished - Apr 1 1978
Externally publishedYes

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Mitochondria
Ions
Valinomycin
Liver Mitochondrion
Electrons
In Vitro Techniques

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

Cite this

Ion movements during energy-linked mitochondrial structural changes. / Webster, Keith A; Bronk, J. R.

In: Journal of Bioenergetics and Biomembranes, Vol. 10, No. 1-2, 01.04.1978, p. 23-44.

Research output: Contribution to journalArticle

Webster, Keith A ; Bronk, J. R. / Ion movements during energy-linked mitochondrial structural changes. In: Journal of Bioenergetics and Biomembranes. 1978 ; Vol. 10, No. 1-2. pp. 23-44.
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