Ion movements during energy-linked mitochondrial structural changes

K. A. Webster, J. R. Bronk

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The structure of isolated rat liver mitochondria has been observed in the electron microscope following incubation of the mitochondria in vitro under a variety of conditions. The results show that ultrastructural changes are only associated with the energization and deenergization of isolated mitochondria if the composition of the incubation medium permits ion movements in or out of the matrix. The mechanism of energy coupling does not appear to depend on these major mitochondrial structural changes. The addition of low levels of valinomycin greatly increases the rate at which the matrix compartment swells and shrinks on energization and deenergization even at low K+ concentrations.

Original languageEnglish (US)
Pages (from-to)23-44
Number of pages22
JournalJournal of Bioenergetics and Biomembranes
Issue number1-2
StatePublished - Apr 1978

ASJC Scopus subject areas

  • Physiology
  • Cell Biology


Dive into the research topics of 'Ion movements during energy-linked mitochondrial structural changes'. Together they form a unique fingerprint.

Cite this