Ion exchange resins: Drug delivery and therapeutic applications

Inderbir Singh, Ashish K. Rehni, Rohit Kalra, Gaurav Joshi, Manoj Kumar, Hassan Y. Aboul-Enein

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Ion exchange resins are water insoluble cross-linked polymers containing a salt-forming group at repeating positions on the polymer chain. They can be classified as cationic or anionic exchange resins depending upon the nature of the exchangeable ion of the resin as a cation or anion, respectively. The degree of cross-linking and particle size of the resin substantially modify its properties and applications. Ion exchange resins can be used to overcome various pharmaceutical formulation problems including bitter taste, poor stability, deliquescence, and poor dissolution of the drugs. Resins have also been used as superdisintegrants in tablet formulations because of their swelling properties. Modified release of drugs from resinate (drug - resin complexes) is another potential application of ion exchange resins. Because of the versatile utility of ion exchange resins, they are being used for various drug delivery and therapeutic applications.

Original languageEnglish (US)
Pages (from-to)91-100
Number of pages10
JournalFabad Journal of Pharmaceutical Sciences
Volume32
Issue number2
StatePublished - Jun 2007
Externally publishedYes

Keywords

  • Exchangeable ion
  • Ion exchange resins
  • Modified release
  • Taste masking

ASJC Scopus subject areas

  • Pharmaceutical Science

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