Involvement of second messengers and protein phosphorylation in astrocyte swelling

A. S. Bender, J. T. Neary, M. D. Norenberg

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


In a hypoosmotic model of astrocyte swelling, we found that Ca2+ and intracellular signals such as diacylglycerol and inositol phosphate, as well as protein phosphorylation systems, are implicated in the generation and (or) modulation of volume regulatory processes. Cyclic AMP, which also has a significant effect on astrocyte volume regulation, in addition influences some of these second messengers.

Original languageEnglish (US)
Pages (from-to)S362-S366
JournalCanadian Journal of Physiology and Pharmacology
Issue numberSUPPL.
StatePublished - 1992


  • astrocyte
  • Ca influx
  • Ca-dependent protein kinases
  • cell volume
  • cyclic AMP
  • inositol phosphates
  • protein phosphorylation

ASJC Scopus subject areas

  • Physiology
  • Pharmacology


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