Involvement of microRNA families in cancer

Stefan Wuchty, Dolores Arjona, Serdar Bozdag, Peter O. Bauer

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Collecting representative sets of cancer microRNAs (miRs) from the literature we show that their corresponding families are enriched in sets of highly interacting miR families. Targeting cancer genes on a statistically significant level, such cancer miR families strongly intervene with signaling pathways that harbor numerous cancer genes. Clustering miR family-specific profiles of pathway intervention, we found that different miR families share similar interaction patterns. Resembling corresponding patterns of cancer miRs families, such interaction patterns may indicate a miR family's potential role in cancer. As we find that the number of targeted cancer genes is a naïve proxy for a cancer miR family, we design a simple method to predict candidate miR families based on gene-specific interaction profiles. Assessing the impact of miR families to distinguish between (non-)cancer genes, we predict a set of 84 potential candidate families, including 75 of initially collected cancer miR families. Further confirming their relevance, predicted cancer miR families are significantly indicated in increasing, non-random numbers of tumor types.

Original languageEnglish (US)
Pages (from-to)8219-8226
Number of pages8
JournalNucleic acids research
Volume40
Issue number17
DOIs
StatePublished - Sep 1 2012

ASJC Scopus subject areas

  • Genetics

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    Wuchty, S., Arjona, D., Bozdag, S., & Bauer, P. O. (2012). Involvement of microRNA families in cancer. Nucleic acids research, 40(17), 8219-8226. https://doi.org/10.1093/nar/gks627