Involvement of long noncoding RNAs in diseases affecting the central nervous system

Chiara Pastori, Claes Wahlestedt

Research output: Contribution to journalReview article

69 Scopus citations

Abstract

DNA sequences associated with protein-coding genes have been the primary focus of most genetic analyses of complex human diseases. Although we are rapidly gaining a comprehensive view of the etiology of certain central nervous system disorders, major gaps in our understanding persist. Recent studies have uncovered that many human genomic sequences are transcribed but not translated, generating an astounding diversity of noncoding RNAs (ncRNAs). This awareness should be taken into account when studying human diseases and may have profound implications on the development of novel biomarkers as well as therapies.

Original languageEnglish (US)
Pages (from-to)860-870
Number of pages11
JournalRNA Biology
Volume9
Issue number6
DOIs
StatePublished - Jun 2012

Keywords

  • Brain cancer
  • Epigenetics
  • Long noncoding RNAs
  • Neurological disorders
  • RNA-binding proteins
  • RNA-targeting therapies

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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