Involvement of H 2L gene products in virus immune T cell recognition. Evidence for an H 2L restricted T cell response

W. E. Biddison, T. H. Hansen, Robert B Levy, P. C. Doherty

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Abstract

The H-2L locus is closely linked to H-2D and codes for antigenic specificities present on a 45,000 mol wt glycoprotein that is distinct from the molecule which bears the D region private specificity. It was found that BALB/c-H-2(db) mice, which lack detectable cell-surface H-2L gene products, were able to generate influenza- and vaccinia-immune cytotoxic T cells which lyse D region-compatible target cells, although they have been reported to be incapable of making a similar response to ectromelia virus (7). Thus, the lack of H-2L antigenic specificities does not produce a general loss of responsiveness for other viruses even when a highly cross-reactive pox virus (vaccinia) was studied. Antisera-blocking experiments utilizing sera specific for either L or D molecules indicated that BALB/c mice generate influenza virus-immune cytotoxic T-cell subsets which independently recognize H-2L and H-2D gene products in association with viral antigens. These results are the first indication that products of the H-2L locus can operate analogously to H-2K/D gene products in virus-immune T-cell recognition.

Original languageEnglish
Pages (from-to)1678-1686
Number of pages9
JournalJournal of Experimental Medicine
Volume148
Issue number6
StatePublished - Dec 1 1978
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

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