Involvement of cavernous sinus region by malignant neoplasms: Report of 5 cases

K. Ahmad, C. Yamokoski, Y. H. Kim, M. J. Post, J. V. Fayos

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9 Scopus citations


Case histories of 5 patients diagnosed as having involvement of the cavernous sinus by metastasis of a malignant tumor are described. In 2 cases, the tumors involved the cavernous sinus region either by direct extension or by invasion along the regional neurovascular structures from tumors of the head and neck area. In 3 cases, involvement was via hematogenous routes from distant sites. Each patient presented initially with signs of third, fourth, fifth, or sixth cranial nerve palsy. As demonstrated by computerized tomographic scanning, the cavernous sinus was the only intracranial site of involvement in all patients. A known history of malignancy and clinical signs suggestive of cavernous sinus involvement are the main diagnostic clinical criteria. High-resolution computed tomographic scanning with contrast enhancement is the radiographic procedure of choice. High doses of irradiation (> 60 Gy) appear to be most beneficial form of treatment for these patients. For patients who have clinical signs indicating a cavernous sinus mass too small to be detected by computed tomography, lower doses of radiation may be adequate.

Original languageEnglish (US)
Pages (from-to)504-508
Number of pages5
JournalJournal of the American Osteopathic Association
Issue number7
StatePublished - Sep 10 1987

ASJC Scopus subject areas

  • Complementary and alternative medicine


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