INVOLUTION OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION AFTER ENDOPHTHALMITIS

Gregg T. Kokame, Nicolas A. Yannuzzi, Jessica G. Shantha, Maya Yamane, Nidhi Relhan, Jeffrey Gross, Edwin H. Ryan, Harry W. Flynn

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: To report patients who demonstrated an alteration in the clinical and optical coherence tomography features of neovascular age-related macular degeneration after resolution of endophthalmitis. METHODS: Retrospective case series of the subsequent changes in the macula and need for anti-vascular endothelial growth factor therapy in patients with neovascular age-related macular degeneration who developed endophthalmitis after intravitreal injection. RESULTS: The study included seven eyes of seven patients with follow-up ranging between 3 months and 11 years. The vitreous cultures (n = 7) before intravitreal antibiotic injection were the following: culture-negative (4) and coagulase-negative Staphylococcus (3). Initial treatment included vitreous tap and injection (4) and pars plana vitrectomy (3). In 5/7 eyes, the optical coherence tomography showed resolution of subretinal fluid and serous pigment epithelial detachment, and there was no additional anti-vascular endothelial growth factor treatment administered. CONCLUSION: After successful treatment of endophthalmitis in patients with neovascular age-related macular degeneration, there was relative involution of the maculopathy and reduced anti-vascular endothelial growth factor treatment burden in this series.

Original languageEnglish (US)
Pages (from-to)495-499
Number of pages5
JournalRetinal cases & brief reports
Volume15
Issue number5
DOIs
StatePublished - Sep 1 2021

ASJC Scopus subject areas

  • Ophthalmology

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