Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome

Raymond Fertig, Jerry Shapiro, Wilma Bergfeld, Antonella Tosti

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Postfinasteride syndrome (PFS) is a term recently coined to characterize a constellation of reported undesirable side effects described in postmarketing reports and small uncontrolled studies that developed during or after stopping finasteride treatment, and persisted after drug discontinuation. Symptoms included decreased libido, erectile dysfunction, sexual anhedonia, decreased sperm count, gynecomastia, skin changes, cognitive impairment, fatigue, anxiety, depression, and suicidal ideation. The aim of this study is to review the existing medical literature for evidence-based research of permanent sexual dysfunction and mood changes during treatment with 5-alpha-reductase inhibitors including finasteride and dutasteride.

Original languageEnglish (US)
Pages (from-to)120-129
Number of pages10
JournalSkin Appendage Disorders
Issue number3-4
StatePublished - 2016


  • Dutasteride
  • Finasteride
  • Permanent sexual dysfunction
  • Physical adverse effects
  • Psyche
  • Psychiatric adverse effects
  • Side effects

ASJC Scopus subject areas

  • Dermatology


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