Investigation of the Plausibility of 5-Alpha-Reductase Inhibitor Syndrome

Raymond Fertig, Jerry Shapiro, Wilma Bergfeld, Antonella Tosti

Research output: Contribution to journalReview article

17 Scopus citations

Abstract

Postfinasteride syndrome (PFS) is a term recently coined to characterize a constellation of reported undesirable side effects described in postmarketing reports and small uncontrolled studies that developed during or after stopping finasteride treatment, and persisted after drug discontinuation. Symptoms included decreased libido, erectile dysfunction, sexual anhedonia, decreased sperm count, gynecomastia, skin changes, cognitive impairment, fatigue, anxiety, depression, and suicidal ideation. The aim of this study is to review the existing medical literature for evidence-based research of permanent sexual dysfunction and mood changes during treatment with 5-alpha-reductase inhibitors including finasteride and dutasteride.

Original languageEnglish (US)
Pages (from-to)120-129
Number of pages10
JournalSkin Appendage Disorders
Volume2
Issue number3-4
DOIs
StatePublished - 2016

Keywords

  • Dutasteride
  • Finasteride
  • Permanent sexual dysfunction
  • Physical adverse effects
  • Psyche
  • Psychiatric adverse effects
  • Side effects

ASJC Scopus subject areas

  • Dermatology

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