Investigation of seven proposed regions of linkage in multiple sclerosis: An American and French collaborative study

Margaret A. Pericak-Vance; Jackie B. Rimmler; Jonathan L. Haines; Melissa E. Garcia; Jorge R. Oksenberg; Lisa F. Barcellos; Robin Lincoln; Stephen L. Hauser; Isabelle Cournu-Rebeix; Ariele Azoulay-Cayla; Olivier Lyon-Caen; Bertrand Fontaine; Emmanuelle Duhamel; Helene Coppin; David Brassat; Marie Paule Roth; Michel Clanet; Mehdi Alizadeh; Jacqueline Yaouanq; Erwann Quelvennec; Gilbert Semana; Gilles Edan; Marie Claude Babron; Emmanuelle Genin; Francoise Clerget-Darpoux

doi:10.1007/s10048-003-0163-y

Investigation of seven proposed regions of linkage in multiple sclerosis: An American and French collaborative study

Margaret A. Pericak-Vance, Jackie B. Rimmler, Jonathan L. Haines, Melissa E. Garcia, Jorge R. Oksenberg, Lisa F. Barcellos, Robin Lincoln, Stephen L. Hauser, Isabelle Cournu-Rebeix, Ariele Azoulay-Cayla, Olivier Lyon-Caen, Bertrand Fontaine, Emmanuelle Duhamel, Helene Coppin, David Brassat, Marie Paule Roth, Michel Clanet, Mehdi Alizadeh, Jacqueline Yaouanq, Erwann QuelvennecGilbert Semana, Gilles Edan, Marie Claude Babron, Emmanuelle Genin, Francoise Clerget-Darpoux

Hussman Institute for Human Genomics

Research output: Contribution to journal › Article

19 Scopus citations

Abstract

Multiple sclerosis (MS) is a demyelinating autoimmune disease with a strong yet complex genetic component. To date only the HLA-DR locus, and specifically the HLA-DR15 allele, has been identified and confirmed as influencing the risk of developing MS. Genomic screens on several datasets have been performed and have identified several chromosomal regions with interesting results, but none have yet been confirmed. We tested seven of the most-promising regions (on chromosomes 1p, 2p, 3p, 3q, 5q, 19q, and Xp) identified from several genomic screens in a dataset of 98 multiplex MS families from the United States and 90 multiplex MS families from France. The results did not confirm linkage to 2p, 3q, 5q, or Xp in the overall dataset, or in subsets defined by geographic origin or HLA-DR15 status. Regions on 1p34, 3p14, and 19q13 produced lod scores >0.90 in at least one subset of the data, suggesting that these regions should be examined in more detail.

Original language	English (US)
Pages (from-to)	45-48
Number of pages	4
Journal	Neurogenetics
Volume	5
Issue number	1
DOIs	https://doi.org/10.1007/s10048-003-0163-y
State	Published - Feb 1 2004

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Keywords

Genetic linkage
Genomic screen
HLA-DR15
Multiple sclerosis
Multiplex families

ASJC Scopus subject areas

Genetics(clinical)
Neuroscience(all)

Cite this

Pericak-Vance, M. A., Rimmler, J. B., Haines, J. L., Garcia, M. E., Oksenberg, J. R., Barcellos, L. F., Lincoln, R., Hauser, S. L., Cournu-Rebeix, I., Azoulay-Cayla, A., Lyon-Caen, O., Fontaine, B., Duhamel, E., Coppin, H., Brassat, D., Roth, M. P., Clanet, M., Alizadeh, M., Yaouanq, J., ... Clerget-Darpoux, F. (2004). Investigation of seven proposed regions of linkage in multiple sclerosis: An American and French collaborative study. Neurogenetics, 5(1), 45-48. https://doi.org/10.1007/s10048-003-0163-y

Investigation of seven proposed regions of linkage in multiple sclerosis : An American and French collaborative study. / Pericak-Vance, Margaret A.; Rimmler, Jackie B.; Haines, Jonathan L.; Garcia, Melissa E.; Oksenberg, Jorge R.; Barcellos, Lisa F.; Lincoln, Robin; Hauser, Stephen L.; Cournu-Rebeix, Isabelle; Azoulay-Cayla, Ariele; Lyon-Caen, Olivier; Fontaine, Bertrand; Duhamel, Emmanuelle; Coppin, Helene; Brassat, David; Roth, Marie Paule; Clanet, Michel; Alizadeh, Mehdi; Yaouanq, Jacqueline; Quelvennec, Erwann; Semana, Gilbert; Edan, Gilles; Babron, Marie Claude; Genin, Emmanuelle; Clerget-Darpoux, Francoise.

In: Neurogenetics, Vol. 5, No. 1, 01.02.2004, p. 45-48.

Research output: Contribution to journal › Article

Pericak-Vance, MA, Rimmler, JB, Haines, JL, Garcia, ME, Oksenberg, JR, Barcellos, LF, Lincoln, R, Hauser, SL, Cournu-Rebeix, I, Azoulay-Cayla, A, Lyon-Caen, O, Fontaine, B, Duhamel, E, Coppin, H, Brassat, D, Roth, MP, Clanet, M, Alizadeh, M, Yaouanq, J, Quelvennec, E, Semana, G, Edan, G, Babron, MC, Genin, E & Clerget-Darpoux, F 2004, 'Investigation of seven proposed regions of linkage in multiple sclerosis: An American and French collaborative study', Neurogenetics, vol. 5, no. 1, pp. 45-48. https://doi.org/10.1007/s10048-003-0163-y

Pericak-Vance, Margaret A. ; Rimmler, Jackie B. ; Haines, Jonathan L. ; Garcia, Melissa E. ; Oksenberg, Jorge R. ; Barcellos, Lisa F. ; Lincoln, Robin ; Hauser, Stephen L. ; Cournu-Rebeix, Isabelle ; Azoulay-Cayla, Ariele ; Lyon-Caen, Olivier ; Fontaine, Bertrand ; Duhamel, Emmanuelle ; Coppin, Helene ; Brassat, David ; Roth, Marie Paule ; Clanet, Michel ; Alizadeh, Mehdi ; Yaouanq, Jacqueline ; Quelvennec, Erwann ; Semana, Gilbert ; Edan, Gilles ; Babron, Marie Claude ; Genin, Emmanuelle ; Clerget-Darpoux, Francoise. / Investigation of seven proposed regions of linkage in multiple sclerosis : An American and French collaborative study. In: Neurogenetics. 2004 ; Vol. 5, No. 1. pp. 45-48.

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N2 - Multiple sclerosis (MS) is a demyelinating autoimmune disease with a strong yet complex genetic component. To date only the HLA-DR locus, and specifically the HLA-DR15 allele, has been identified and confirmed as influencing the risk of developing MS. Genomic screens on several datasets have been performed and have identified several chromosomal regions with interesting results, but none have yet been confirmed. We tested seven of the most-promising regions (on chromosomes 1p, 2p, 3p, 3q, 5q, 19q, and Xp) identified from several genomic screens in a dataset of 98 multiplex MS families from the United States and 90 multiplex MS families from France. The results did not confirm linkage to 2p, 3q, 5q, or Xp in the overall dataset, or in subsets defined by geographic origin or HLA-DR15 status. Regions on 1p34, 3p14, and 19q13 produced lod scores >0.90 in at least one subset of the data, suggesting that these regions should be examined in more detail.

AB - Multiple sclerosis (MS) is a demyelinating autoimmune disease with a strong yet complex genetic component. To date only the HLA-DR locus, and specifically the HLA-DR15 allele, has been identified and confirmed as influencing the risk of developing MS. Genomic screens on several datasets have been performed and have identified several chromosomal regions with interesting results, but none have yet been confirmed. We tested seven of the most-promising regions (on chromosomes 1p, 2p, 3p, 3q, 5q, 19q, and Xp) identified from several genomic screens in a dataset of 98 multiplex MS families from the United States and 90 multiplex MS families from France. The results did not confirm linkage to 2p, 3q, 5q, or Xp in the overall dataset, or in subsets defined by geographic origin or HLA-DR15 status. Regions on 1p34, 3p14, and 19q13 produced lod scores >0.90 in at least one subset of the data, suggesting that these regions should be examined in more detail.

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10.1007/s10048-003-0163-y