TY - JOUR
T1 - Investigation of seven proposed regions of linkage in multiple sclerosis
T2 - An American and French collaborative study
AU - Pericak-Vance, Margaret A.
AU - Rimmler, Jackie B.
AU - Haines, Jonathan L.
AU - Garcia, Melissa E.
AU - Oksenberg, Jorge R.
AU - Barcellos, Lisa F.
AU - Lincoln, Robin
AU - Hauser, Stephen L.
AU - Cournu-Rebeix, Isabelle
AU - Azoulay-Cayla, Ariele
AU - Lyon-Caen, Olivier
AU - Fontaine, Bertrand
AU - Duhamel, Emmanuelle
AU - Coppin, Helene
AU - Brassat, David
AU - Roth, Marie Paule
AU - Clanet, Michel
AU - Alizadeh, Mehdi
AU - Yaouanq, Jacqueline
AU - Quelvennec, Erwann
AU - Semana, Gilbert
AU - Edan, Gilles
AU - Babron, Marie Claude
AU - Genin, Emmanuelle
AU - Clerget-Darpoux, Francoise
PY - 2004/2
Y1 - 2004/2
N2 - Multiple sclerosis (MS) is a demyelinating autoimmune disease with a strong yet complex genetic component. To date only the HLA-DR locus, and specifically the HLA-DR15 allele, has been identified and confirmed as influencing the risk of developing MS. Genomic screens on several datasets have been performed and have identified several chromosomal regions with interesting results, but none have yet been confirmed. We tested seven of the most-promising regions (on chromosomes 1p, 2p, 3p, 3q, 5q, 19q, and Xp) identified from several genomic screens in a dataset of 98 multiplex MS families from the United States and 90 multiplex MS families from France. The results did not confirm linkage to 2p, 3q, 5q, or Xp in the overall dataset, or in subsets defined by geographic origin or HLA-DR15 status. Regions on 1p34, 3p14, and 19q13 produced lod scores >0.90 in at least one subset of the data, suggesting that these regions should be examined in more detail.
AB - Multiple sclerosis (MS) is a demyelinating autoimmune disease with a strong yet complex genetic component. To date only the HLA-DR locus, and specifically the HLA-DR15 allele, has been identified and confirmed as influencing the risk of developing MS. Genomic screens on several datasets have been performed and have identified several chromosomal regions with interesting results, but none have yet been confirmed. We tested seven of the most-promising regions (on chromosomes 1p, 2p, 3p, 3q, 5q, 19q, and Xp) identified from several genomic screens in a dataset of 98 multiplex MS families from the United States and 90 multiplex MS families from France. The results did not confirm linkage to 2p, 3q, 5q, or Xp in the overall dataset, or in subsets defined by geographic origin or HLA-DR15 status. Regions on 1p34, 3p14, and 19q13 produced lod scores >0.90 in at least one subset of the data, suggesting that these regions should be examined in more detail.
KW - Genetic linkage
KW - Genomic screen
KW - HLA-DR15
KW - Multiple sclerosis
KW - Multiplex families
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U2 - 10.1007/s10048-003-0163-y
DO - 10.1007/s10048-003-0163-y
M3 - Article
C2 - 14595552
AN - SCOPUS:10744231697
VL - 5
SP - 45
EP - 48
JO - Neurogenetics
JF - Neurogenetics
SN - 1364-6745
IS - 1
ER -