Investigation of different combinations of estrogen therapy and radiation therapy on prostatic adenocarcinoma (R-3327)

Freddy Camuzzi, Charles Gottlieb, Norman L. Block, Komanduri Charyulu, Betty Stover, Victor A. Politano

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The relative effectiveness of different combinations of estrogen therapy and radiation therapy against the R-3327 prostatic adenocarcinoma of the Copenhagen rat was studied. Because of similar actions of estrogens and radiation in the cell cycle, and possibly antagonistic effects reported in the clinical literature, we looked for an antagonism between these two therapeutic modalities. Radiation therapy consistently showed a greater tumor inhibitory effect than estrogen therapy alone at the dose tested. Combinations of radiation therapy with hormonal manipulation did not appear to show a greater inhibition of tumor growth than radiation therapy alone. There also did not appear to be an antagonistic effect between these two modalities in this system.

Original languageEnglish (US)
Pages (from-to)443-447
Number of pages5
JournalUrology
Volume15
Issue number5
DOIs
StatePublished - May 1980

ASJC Scopus subject areas

  • Urology

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