Investigating tissue optical properties and texture descriptors of the retina in patients with multiple sclerosis

Boglárka Enikö Varga, Wei Gao, Kornélia Lenke Laurik, Erika Tátrai, Magdolna Simó, Gábor Márk Somfai, Delia Cabrera DeBuc

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose: To assess the differences in texture descriptors and optical properties of retinal tissue layers in patients with multiple sclerosis (MS) and to evaluate their usefulness in the detection of neurodegenerative changes using optical coherence tomography (OCT) image segmentation. Patients and Methods: 38 patients with MS were examined using Stratus OCT. The raw macular OCT data were exported and processed using OCTRIMA software. The enrolled eyes were divided into two groups, based on the presence of optic neuritis (ON) in the history (MSON+ group, n = 36 and MSON- group, n = 31). Data of 29 eyes of 24 healthy subjects (H) were used as controls. A total of seven intraretinal layers were segmented and thickness as well as optical parameters such as contrast, fractal dimension, layer index and total reflectance were measured. Mixed-model ANOVA analysis was used for statistical comparisons. Results: Significant thinning of the retinal nerve fiber layer (RNFL), ganglion cell/inner plexiform layer complex (GCL+IPL) and ganglion cell complex (GCC, RNFL+GCL+IPL) was observed between study groups in all comparisons. Significant difference was found in contrast in the RNFL, GCL+IPL, GCC, inner nuclear layer (INL) and outer plexiform layer when comparing MSON+ to the other groups. Higher fractal dimension values were observed in GCL+IPL and INL layers when comparing H vs. MSON+ groups. A significant difference was found in layer index in the RNFL, GCL+IPL and GCC layers in all comparisons. A significant difference was observed in total reflectance in the RNFL, GCL+IPL and GCC layers between the three examination groups. Conclusion: Texture and optical properties of the retinal tissue undergo pronounced changes in MS even without optic neuritis. Our results may help to further improve the diagnostic efficacy of OCT in MS and neurodegeneration.

Original languageEnglish (US)
Article numbere0143711
JournalPLoS One
Volume10
Issue number11
DOIs
StatePublished - Nov 1 2015

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optical properties
sclerosis
nerve fibers
Nerve Fibers
retina
Multiple Sclerosis
Optical tomography
tomography
Optical Coherence Tomography
Retina
Optical properties
Textures
texture
Tissue
Fibers
Optic Neuritis
Fractals
fractal dimensions
Fractal dimension
optics

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Investigating tissue optical properties and texture descriptors of the retina in patients with multiple sclerosis. / Varga, Boglárka Enikö; Gao, Wei; Laurik, Kornélia Lenke; Tátrai, Erika; Simó, Magdolna; Somfai, Gábor Márk; Cabrera DeBuc, Delia.

In: PLoS One, Vol. 10, No. 11, e0143711, 01.11.2015.

Research output: Contribution to journalArticle

Varga, Boglárka Enikö ; Gao, Wei ; Laurik, Kornélia Lenke ; Tátrai, Erika ; Simó, Magdolna ; Somfai, Gábor Márk ; Cabrera DeBuc, Delia. / Investigating tissue optical properties and texture descriptors of the retina in patients with multiple sclerosis. In: PLoS One. 2015 ; Vol. 10, No. 11.
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abstract = "Purpose: To assess the differences in texture descriptors and optical properties of retinal tissue layers in patients with multiple sclerosis (MS) and to evaluate their usefulness in the detection of neurodegenerative changes using optical coherence tomography (OCT) image segmentation. Patients and Methods: 38 patients with MS were examined using Stratus OCT. The raw macular OCT data were exported and processed using OCTRIMA software. The enrolled eyes were divided into two groups, based on the presence of optic neuritis (ON) in the history (MSON+ group, n = 36 and MSON- group, n = 31). Data of 29 eyes of 24 healthy subjects (H) were used as controls. A total of seven intraretinal layers were segmented and thickness as well as optical parameters such as contrast, fractal dimension, layer index and total reflectance were measured. Mixed-model ANOVA analysis was used for statistical comparisons. Results: Significant thinning of the retinal nerve fiber layer (RNFL), ganglion cell/inner plexiform layer complex (GCL+IPL) and ganglion cell complex (GCC, RNFL+GCL+IPL) was observed between study groups in all comparisons. Significant difference was found in contrast in the RNFL, GCL+IPL, GCC, inner nuclear layer (INL) and outer plexiform layer when comparing MSON+ to the other groups. Higher fractal dimension values were observed in GCL+IPL and INL layers when comparing H vs. MSON+ groups. A significant difference was found in layer index in the RNFL, GCL+IPL and GCC layers in all comparisons. A significant difference was observed in total reflectance in the RNFL, GCL+IPL and GCC layers between the three examination groups. Conclusion: Texture and optical properties of the retinal tissue undergo pronounced changes in MS even without optic neuritis. Our results may help to further improve the diagnostic efficacy of OCT in MS and neurodegeneration.",
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AU - Laurik, Kornélia Lenke

AU - Tátrai, Erika

AU - Simó, Magdolna

AU - Somfai, Gábor Márk

AU - Cabrera DeBuc, Delia

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