Investigating the acoustic release of doxorubicin from targeted micelles

Ghaleb A. Husseini, Diana Velluto, Laura Kherbeck, William G. Pitt, Jeffrey A. Hubbell, Douglas A. Christensen

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The main problem associated with the administration of anti-cancer medication is that the drug is delivered throughout the body causing undesirable side effects. Therefore, it is important to synthesize drug carriers capable of minimizing the adverse side effects of chemotherapy by preferentially targeting tumor cells both actively (e.g. a folate receptor) and using external stimulus (e.g. ultrasound). In this paper, we report the synthesis of Pluronic P105 micelles with a folate targeting moiety (with a yield of 48%) containing doxorubicin (Dox). We applied low frequency ultrasound as an external stimulus and measured the amount of release of Dox from these folated micelles. The results showed that the percent drug release increases as the power intensity of ultrasound increases. The maximum amount of release (14%) was measured at 5.4W/cm2. A power density threshold at approximately 0.55W/cm2 exists below which no statistically significant release was observed. This lower threshold suggests that cavitation plays an important role in triggering drug release from targeted micelles.

Original languageEnglish
Pages (from-to)153-155
Number of pages3
JournalColloids and Surfaces B: Biointerfaces
Volume101
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Fingerprint

Micelles
Acoustics
Doxorubicin
micelles
drugs
Ultrasonics
Folic Acid
acoustics
Pharmaceutical Preparations
stimuli
Drug Carriers
Chemotherapy
Cavitation
thresholds
Tumors
Neoplasms
chemotherapy
cavitation flow
Cells
radiant flux density

Keywords

  • 70-kHz ultrasound
  • Cavitation
  • Doxorubicin
  • Drug release
  • Folic acid
  • Pluronic P105
  • Polymeric micelles

ASJC Scopus subject areas

  • Biotechnology
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Surfaces and Interfaces

Cite this

Husseini, G. A., Velluto, D., Kherbeck, L., Pitt, W. G., Hubbell, J. A., & Christensen, D. A. (2013). Investigating the acoustic release of doxorubicin from targeted micelles. Colloids and Surfaces B: Biointerfaces, 101, 153-155. https://doi.org/10.1016/j.colsurfb.2012.05.025

Investigating the acoustic release of doxorubicin from targeted micelles. / Husseini, Ghaleb A.; Velluto, Diana; Kherbeck, Laura; Pitt, William G.; Hubbell, Jeffrey A.; Christensen, Douglas A.

In: Colloids and Surfaces B: Biointerfaces, Vol. 101, 01.01.2013, p. 153-155.

Research output: Contribution to journalArticle

Husseini, GA, Velluto, D, Kherbeck, L, Pitt, WG, Hubbell, JA & Christensen, DA 2013, 'Investigating the acoustic release of doxorubicin from targeted micelles', Colloids and Surfaces B: Biointerfaces, vol. 101, pp. 153-155. https://doi.org/10.1016/j.colsurfb.2012.05.025
Husseini, Ghaleb A. ; Velluto, Diana ; Kherbeck, Laura ; Pitt, William G. ; Hubbell, Jeffrey A. ; Christensen, Douglas A. / Investigating the acoustic release of doxorubicin from targeted micelles. In: Colloids and Surfaces B: Biointerfaces. 2013 ; Vol. 101. pp. 153-155.
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