Inverse relationship between CSF TRH concentrations and the TSH response to TRH in abstinent alcohol-dependent patients

Bryon Adinoff, Charles B. Nemeroff, Garth Bissette, Peter R. Martin, Markku Linnoila

Research output: Contribution to journalArticle

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The authors performed the thyrotropin-releasing hormone (TRH) stimulation test and measured CSF concentrations of TRH in 13 abstinent alcohol-dependent subjects. They found an inverse correlation between the thyrotropin (TSH) response to TRH and endogenous CSF TRH concentrations. This finding supports the hypothesis that as the concentration of CSF TRH increases, anterior pituitary TRH receptor density decreases, resulting in a blunted TSH response to TRH stimulation.

Original languageEnglish (US)
Pages (from-to)1586-1588
Number of pages3
JournalAmerican Journal of Psychiatry
Issue number11
StatePublished - Jan 1 1991
Externally publishedYes


ASJC Scopus subject areas

  • Psychiatry and Mental health

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