Abstract
Women with recurrent urinary tract infection (UTI) often demonstrate persistent vaginal colonization with Escherichia coli. Since strains of lactobacilli that produce hydrogen peroxide inhibit the growth of E. coli, the absence of these strains may predispose to E. coli colonization and to UTI. To test this hypothesis, vaginal introitai cultures were obtained from 140 women, 65 with recurrent UTI (case-patients) and 75 without (controls). Vaginal E. coli colonization was significantly more frequent in case-patients than controls (35% vs. 11%; P < .001) and in women without H2O2-positive lactobaciili than in women with (odds ratio [OR], 4.0; P = .01). Spermicide use was associated with greater risk of vaginal E. coli colonization (OR, 12.5; P < .001) and with absence of H2O2-positive lactobacilli (OR, 2.9; P = .04). The inverse association between H2O2-positive lactobacilli and vaginal E. coli colonization remained in case-patients after controlling for spermicide use (OR, 6.5; P = .02). Thus, absence of H2O2-positive lactobaciili may be important in the pathogenesis of recurrent UTI by facilitating E. coli introitai colonization.
| Original language | English |
|---|---|
| Pages (from-to) | 446-450 |
| Number of pages | 5 |
| Journal | Journal of Infectious Diseases |
| Volume | 178 |
| Issue number | 2 |
| State | Published - Jan 1 1998 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Public Health, Environmental and Occupational Health
Cite this
Inverse association of H2O2-producing lactobacilli and vaginal Escherichia coli colonization in women with recurrent urinary tract infections. / Gupta, Kalpana; Stapleton, Ann E.; Hooton, Thomas; Roberts, Pacita L.; Fennell, Cynthia L.; Stamm, Walter E.
In: Journal of Infectious Diseases, Vol. 178, No. 2, 01.01.1998, p. 446-450.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inverse association of H2O2-producing lactobacilli and vaginal Escherichia coli colonization in women with recurrent urinary tract infections
AU - Gupta, Kalpana
AU - Stapleton, Ann E.
AU - Hooton, Thomas
AU - Roberts, Pacita L.
AU - Fennell, Cynthia L.
AU - Stamm, Walter E.
PY - 1998/1/1
Y1 - 1998/1/1
N2 - Women with recurrent urinary tract infection (UTI) often demonstrate persistent vaginal colonization with Escherichia coli. Since strains of lactobacilli that produce hydrogen peroxide inhibit the growth of E. coli, the absence of these strains may predispose to E. coli colonization and to UTI. To test this hypothesis, vaginal introitai cultures were obtained from 140 women, 65 with recurrent UTI (case-patients) and 75 without (controls). Vaginal E. coli colonization was significantly more frequent in case-patients than controls (35% vs. 11%; P < .001) and in women without H2O2-positive lactobaciili than in women with (odds ratio [OR], 4.0; P = .01). Spermicide use was associated with greater risk of vaginal E. coli colonization (OR, 12.5; P < .001) and with absence of H2O2-positive lactobacilli (OR, 2.9; P = .04). The inverse association between H2O2-positive lactobacilli and vaginal E. coli colonization remained in case-patients after controlling for spermicide use (OR, 6.5; P = .02). Thus, absence of H2O2-positive lactobaciili may be important in the pathogenesis of recurrent UTI by facilitating E. coli introitai colonization.
AB - Women with recurrent urinary tract infection (UTI) often demonstrate persistent vaginal colonization with Escherichia coli. Since strains of lactobacilli that produce hydrogen peroxide inhibit the growth of E. coli, the absence of these strains may predispose to E. coli colonization and to UTI. To test this hypothesis, vaginal introitai cultures were obtained from 140 women, 65 with recurrent UTI (case-patients) and 75 without (controls). Vaginal E. coli colonization was significantly more frequent in case-patients than controls (35% vs. 11%; P < .001) and in women without H2O2-positive lactobaciili than in women with (odds ratio [OR], 4.0; P = .01). Spermicide use was associated with greater risk of vaginal E. coli colonization (OR, 12.5; P < .001) and with absence of H2O2-positive lactobacilli (OR, 2.9; P = .04). The inverse association between H2O2-positive lactobacilli and vaginal E. coli colonization remained in case-patients after controlling for spermicide use (OR, 6.5; P = .02). Thus, absence of H2O2-positive lactobaciili may be important in the pathogenesis of recurrent UTI by facilitating E. coli introitai colonization.
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UR - http://www.scopus.com/inward/citedby.url?scp=0031596222&partnerID=8YFLogxK
M3 - Article
C2 - 9697725
AN - SCOPUS:0031596222
VL - 178
SP - 446
EP - 450
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 2
ER -