Inverse association of H2O2-producing lactobacilli and vaginal Escherichia coli colonization in women with recurrent urinary tract infections

Kalpana Gupta, Ann E. Stapleton, Thomas Hooton, Pacita L. Roberts, Cynthia L. Fennell, Walter E. Stamm

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

Women with recurrent urinary tract infection (UTI) often demonstrate persistent vaginal colonization with Escherichia coli. Since strains of lactobacilli that produce hydrogen peroxide inhibit the growth of E. coli, the absence of these strains may predispose to E. coli colonization and to UTI. To test this hypothesis, vaginal introitai cultures were obtained from 140 women, 65 with recurrent UTI (case-patients) and 75 without (controls). Vaginal E. coli colonization was significantly more frequent in case-patients than controls (35% vs. 11%; P < .001) and in women without H2O2-positive lactobaciili than in women with (odds ratio [OR], 4.0; P = .01). Spermicide use was associated with greater risk of vaginal E. coli colonization (OR, 12.5; P < .001) and with absence of H2O2-positive lactobacilli (OR, 2.9; P = .04). The inverse association between H2O2-positive lactobacilli and vaginal E. coli colonization remained in case-patients after controlling for spermicide use (OR, 6.5; P = .02). Thus, absence of H2O2-positive lactobaciili may be important in the pathogenesis of recurrent UTI by facilitating E. coli introitai colonization.

Original languageEnglish
Pages (from-to)446-450
Number of pages5
JournalJournal of Infectious Diseases
Volume178
Issue number2
StatePublished - Jan 1 1998
Externally publishedYes

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Lactobacillus
Urinary Tract Infections
Escherichia coli
Odds Ratio
Hydrogen Peroxide
Growth

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Inverse association of H2O2-producing lactobacilli and vaginal Escherichia coli colonization in women with recurrent urinary tract infections. / Gupta, Kalpana; Stapleton, Ann E.; Hooton, Thomas; Roberts, Pacita L.; Fennell, Cynthia L.; Stamm, Walter E.

In: Journal of Infectious Diseases, Vol. 178, No. 2, 01.01.1998, p. 446-450.

Research output: Contribution to journalArticle

Gupta, Kalpana ; Stapleton, Ann E. ; Hooton, Thomas ; Roberts, Pacita L. ; Fennell, Cynthia L. ; Stamm, Walter E. / Inverse association of H2O2-producing lactobacilli and vaginal Escherichia coli colonization in women with recurrent urinary tract infections. In: Journal of Infectious Diseases. 1998 ; Vol. 178, No. 2. pp. 446-450.
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