Invasive fusariosis masquerading as extramedullary disease in rapidly progressive acute lymphoblastic leukemia

John A. Ligon, Mukil Natarajan, Haneen Shalabi, Bonnie Yates, Rachel Bishop, David Bianchi, Alvaro Alencar, Michail S. Lionakis, Nirali N. Shah

Research output: Contribution to journalArticlepeer-review

Abstract

Invasive fusariosis (IF) most commonly occurs in patients with hematologic malignancies and severe neutropenia, particularly during concomitant corticosteroid use. Breakthrough infections can occur in high-risk patients despite Aspergillus-active antifungal prophylaxis. We describe a patient with rapid acute lymphoblastic leukemia (ALL) progression who presented with multifocal skin nodules thought to be choloromatous disease. These lesions were ultimately diagnosed as IF and the patient had two simultaneously active disease processes. This case highlights the importance of pathologic diagnosis of new skin lesions in ALL patients, even during leukemia progression, and demonstrates that IF can occur despite normal neutrophil counts and Aspergillus-active prophylaxis.

Original languageEnglish (US)
Article numbere27732
JournalPediatric Blood and Cancer
Volume66
Issue number7
DOIs
StatePublished - Jul 2019

Keywords

  • acute lymphoblastic leukemia
  • Fusarium
  • immunocompromised
  • invasive fungal infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Fingerprint

Dive into the research topics of 'Invasive fusariosis masquerading as extramedullary disease in rapidly progressive acute lymphoblastic leukemia'. Together they form a unique fingerprint.

Cite this