Introductory comments on blood flow autoregulation in the optic nerve head and vascular risk factors in glaucoma

Douglas Anderson

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

It is widely suspected that tissue ischemia initiates or participates in optic disk damage in glaucoma. The details are not well delineated. Particularly puzzling is the clear separation of the clinical appearances of glaucoma and anterior ischemic optic neuropathy, which is also a presumed ischemic disease. When venous pressure at the exit point from the eye is elevated by intraocular pressure (IOP), the arteriovenous pressure difference is reduced. Nutrition is maintained only because of blood flow autoregulation. Intraocular pressure-induced ischemia can result if autoregulation is impaired in an individual, either because of an innate deficiency or, perhaps, as a result of vasospastic disease. Autoregulation can also be impaired if another disease (e.g., an atheroma) has caused much of the autoregulatory capacity to be already utilized, so that little or none is left to respond to the additional challenge of IOP. Ischemia might also result from microvascular occlusion with platelet or clotting abnormalities, perhaps inducing glaucomatous optic neuropathy that is not dependent on IOP. A better understanding of the pathogenic mechanism (and how it may be different in various cases) is needed to predict more successfully an individual's risk of glaucomatous damage, to make decisions about the aggressiveness of treatment, and, one day, to direct therapy at the type of vascular abnormality present, in addition to or instead of lowering IOP.

Original languageEnglish
JournalSurvey of Ophthalmology
Volume43
Issue number6 SUPPL.
DOIs
StatePublished - Jun 1 1999

Fingerprint

Optic Disk
Intraocular Pressure
Glaucoma
Homeostasis
Ischemia
Ischemic Optic Neuropathy
Optic Nerve Diseases
Venous Pressure
Atherosclerotic Plaques
Blood Vessels
Blood Platelets
vascular factor
Pressure

Keywords

  • Autoregulation
  • Blood flow
  • Glaucoma
  • Optic nerve head
  • Pericytes

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Introductory comments on blood flow autoregulation in the optic nerve head and vascular risk factors in glaucoma. / Anderson, Douglas.

In: Survey of Ophthalmology, Vol. 43, No. 6 SUPPL., 01.06.1999.

Research output: Contribution to journalArticle

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