Abstract
Beginning with the first reports in 2001 and continuing to the present time, exposed bone in the jaws and, more recently, femoral fractures caused by the toxic effects of bisphosphonates on osteoclasts have become epidemic. In less than 10 years, more than 1,100 publications have been published on bisphosphonates-induced osteonecrosis of the jaw (BIONJ). 16 organizations have produced position papers, and tens of thousands of individuals have been afflicted by this serious drug-induced adverse side effect. The predictability of BIONJ occurring in humans has long been recognized, in the historical accounts of the phossy jaw epidemic between 1850 and 1906 and in the disease of osteopetrosis. BIONJ, as well as both of these pathologies, results from the over suppression of bone turnover (renewal), such that brittle and often necrotic bone develops in areas of the skeleton subject to the highest turnover in response to compressive forces and bending forces (e.g., alveolar bone in the jaws and the mid femur). The current challenge to clinicians is not to be ambivalent concerning the cause of BIONJ, as it is due to the bisphosphonate molecule itself, with all other medical conditions and drugs playing only contributing roles as co-morbidities. Accordingly, both the dose and the frequency of administration must be moderated. In addition, dental/oral and maxillofacial surgical teams must be able to competently manage and treat these individuals to control or resolve the disease.
| Original language | English (US) |
|---|---|
| Title of host publication | Bisphosphonates and Osteonecrosis of the Jaw: A Multidisciplinary Approach |
| Publisher | Springer-Verlag Italia s.r.l. |
| Pages | 1-11 |
| Number of pages | 11 |
| Volume | 9788847020832 |
| ISBN (Print) | 9788847020832, 8847020824, 9788847020825 |
| DOIs | |
| State | Published - May 1 2011 |
Fingerprint
Keywords
- Bisphosphonate-induced osteonecrosis
- Bisphosphonates
- Exposed bone
- Femur fractures
- Fosamax
- Osteoclasts
- Phossy jaw
- Strike anywhere matches
- White phosphorus
- Zometa
ASJC Scopus subject areas
- Medicine(all)
Cite this
Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Introduction
AU - Marx, Robert
PY - 2011/5/1
Y1 - 2011/5/1
N2 - Beginning with the first reports in 2001 and continuing to the present time, exposed bone in the jaws and, more recently, femoral fractures caused by the toxic effects of bisphosphonates on osteoclasts have become epidemic. In less than 10 years, more than 1,100 publications have been published on bisphosphonates-induced osteonecrosis of the jaw (BIONJ). 16 organizations have produced position papers, and tens of thousands of individuals have been afflicted by this serious drug-induced adverse side effect. The predictability of BIONJ occurring in humans has long been recognized, in the historical accounts of the phossy jaw epidemic between 1850 and 1906 and in the disease of osteopetrosis. BIONJ, as well as both of these pathologies, results from the over suppression of bone turnover (renewal), such that brittle and often necrotic bone develops in areas of the skeleton subject to the highest turnover in response to compressive forces and bending forces (e.g., alveolar bone in the jaws and the mid femur). The current challenge to clinicians is not to be ambivalent concerning the cause of BIONJ, as it is due to the bisphosphonate molecule itself, with all other medical conditions and drugs playing only contributing roles as co-morbidities. Accordingly, both the dose and the frequency of administration must be moderated. In addition, dental/oral and maxillofacial surgical teams must be able to competently manage and treat these individuals to control or resolve the disease.
AB - Beginning with the first reports in 2001 and continuing to the present time, exposed bone in the jaws and, more recently, femoral fractures caused by the toxic effects of bisphosphonates on osteoclasts have become epidemic. In less than 10 years, more than 1,100 publications have been published on bisphosphonates-induced osteonecrosis of the jaw (BIONJ). 16 organizations have produced position papers, and tens of thousands of individuals have been afflicted by this serious drug-induced adverse side effect. The predictability of BIONJ occurring in humans has long been recognized, in the historical accounts of the phossy jaw epidemic between 1850 and 1906 and in the disease of osteopetrosis. BIONJ, as well as both of these pathologies, results from the over suppression of bone turnover (renewal), such that brittle and often necrotic bone develops in areas of the skeleton subject to the highest turnover in response to compressive forces and bending forces (e.g., alveolar bone in the jaws and the mid femur). The current challenge to clinicians is not to be ambivalent concerning the cause of BIONJ, as it is due to the bisphosphonate molecule itself, with all other medical conditions and drugs playing only contributing roles as co-morbidities. Accordingly, both the dose and the frequency of administration must be moderated. In addition, dental/oral and maxillofacial surgical teams must be able to competently manage and treat these individuals to control or resolve the disease.
KW - Bisphosphonate-induced osteonecrosis
KW - Bisphosphonates
KW - Exposed bone
KW - Femur fractures
KW - Fosamax
KW - Osteoclasts
KW - Phossy jaw
KW - Strike anywhere matches
KW - White phosphorus
KW - Zometa
UR - http://www.scopus.com/inward/record.url?scp=84930856588&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930856588&partnerID=8YFLogxK
U2 - 10.1007/978-88-470-2083-2_1
DO - 10.1007/978-88-470-2083-2_1
M3 - Chapter
SN - 9788847020832
SN - 8847020824
SN - 9788847020825
VL - 9788847020832
SP - 1
EP - 11
BT - Bisphosphonates and Osteonecrosis of the Jaw: A Multidisciplinary Approach
PB - Springer-Verlag Italia s.r.l.
ER -