Intrinsic factor deficiency in adults with normal hydrochloric acid production

J. C. Meeroff, D. Zagalsky, M. Meeroff

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Two cases of intrinsic factor deficiency with normal hydrochloric acid production are presented. Both patients had markedly reduced intrinsic factor secretion and substantial titers of type I (blocking) intrinsic factor antibodies. No parietal cell antibodies were recognized by immunofluorescence in either case. Three hypotheses are offered to explain these findings: (a) These patients have congenital intrinsic factor deficiency that remained in the preanemic phase until adulthood; (b) they have pernicious anemia detected at a stage before gastric mucosal atrophy and achlorhydria have occurred; or (c) they represent cases of a new syndrome characterized by isolated intrinsic factor deficiency.

Original languageEnglish (US)
Pages (from-to)575-577
Number of pages3
Issue number3
StatePublished - Mar 1981
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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