Abstract
Two cases of intrinsic factor deficiency with normal hydrochloric acid production are presented. Both patients had markedly reduced intrinsic factor secretion and substantial titers of type I (blocking) intrinsic factor antibodies. No parietal cell antibodies were recognized by immunofluorescence in either case. Three hypotheses are offered to explain these findings: (a) These patients have congenital intrinsic factor deficiency that remained in the preanemic phase until adulthood; (b) they have pernicious anemia detected at a stage before gastric mucosal atrophy and achlorhydria have occurred; or (c) they represent cases of a new syndrome characterized by isolated intrinsic factor deficiency.
Original language | English (US) |
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Pages (from-to) | 575-577 |
Number of pages | 3 |
Journal | Gastroenterology |
Volume | 80 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1981 |
ASJC Scopus subject areas
- Hepatology
- Gastroenterology