Intravoxel incoherent motion imaging for assessment of bone marrow infiltration of monoclonal plasma cell diseases

Rajiv Shah, Bram Stieltjes, Mindaugas Andrulis, Ruth Pfeiffer, Migle Sumkauskaite, Stefan Delorme, Heinz Peter Schlemmer, Hartmut Goldschmidt, Ola Landgren, Jens Hillengass

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Modern imaging techniques have demonstrated that monoclonal plasma cell diseases infiltrate the bone marrow in a diffuse, focal, mixed pattern. While focal lesions can be easily counted and measured, the diffuse lesions of the infiltration are hard to assess. We therefore investigated 31 patients with monoclonal plasma cell diseases of all stages with intravoxel incoherent motion imaging of the same region of the pelvis from where afterwards a biopsy was obtained. We found a significant correlation between plasma cell percentage in bone marrow histology and the imaging parameters "apparent diffusion coefficient" and the diffusion coefficient D. Furthermore, those parameters correlated with other factors of disease activity, e.g., monoclonal protein, hemoglobin, and immunoparesis. In summary, we found that the non-invasively acquired imaging parameters correlated with the degree of plasma cell infiltration in the bone marrow.

Original languageEnglish (US)
Pages (from-to)1553-1557
Number of pages5
JournalAnnals of Hematology
Volume92
Issue number11
DOIs
StatePublished - Nov 2013
Externally publishedYes

Keywords

  • Cellularity
  • Diffusion-weighted imaging
  • Microcirculation
  • Monoclonal gammopathy of undetermined significance
  • Multiple myeloma

ASJC Scopus subject areas

  • Hematology

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