Intravitreal injection analysis at the Bascom palmer eye institute: Evaluation of clinical indications for the treatment and incidence rates of endophthalmitis

Ludimila L. Cavalcante, Milena L. Cavalcante, Timothy G. Murray, Michael M. Vigoda, Yolanda Piña, Christina L. Decatur, R. Prince Davis, Lisa C. Olmos, Amy C. Schefler, Michael B. Parrott, Kyle J. Alliman, Harry W. Flynn, Andrew A. Moshfeghi

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Objective: To report the incidence of endophthalmitis, in addition to its clinical and microbiological aspects, after intravitreal injection of vascular-targeting agents. Methods: A retrospective review of a consecutive series of 10,142 intravitreal injectionsof vasculartargeting agents (bevacizumab, ranibizumab, triamcinolone acetonide, andpreservative-free triamcinolone acetonide) between June 1, 2007 and January 31, 2010,performedby a single service (TGM) at the Bascom Palmer Eye Institute. Results: One case of clinically-suspected endophthalmitis was identified out of a total of 10,142injections (0.009%), presenting within three days of injection of bevacizumab. The case wasculture-positive for Staphylococcus epidermidis. Final visual acuity was 20/40 after pars planavitrectomy surgery. Conclusions: In this series, the incidence of culture-positive endophthalmitis after intravitrealinjection of vascular agents in an outpatient setting was very low. We believe that following astandardized injection protocol, adherence to sterile techniques and proper patient follow-upare determining factors for low incidence rates.

Original languageEnglish (US)
Pages (from-to)519-524
Number of pages6
JournalClinical Ophthalmology
Volume4
Issue number1
DOIs
StatePublished - 2010

Keywords

  • Endophthalmitis
  • Intravitreal injections
  • Vascular targeting agent

ASJC Scopus subject areas

  • Ophthalmology

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    Cavalcante, L. L., Cavalcante, M. L., Murray, T. G., Vigoda, M. M., Piña, Y., Decatur, C. L., Davis, R. P., Olmos, L. C., Schefler, A. C., Parrott, M. B., Alliman, K. J., Flynn, H. W., & Moshfeghi, A. A. (2010). Intravitreal injection analysis at the Bascom palmer eye institute: Evaluation of clinical indications for the treatment and incidence rates of endophthalmitis. Clinical Ophthalmology, 4(1), 519-524. https://doi.org/10.2147/opth.s11094