Abstract
Delivery of acetylsalicylic acid by intravitreal silicone oil was investigated for safety and for its pharmacokinetics in the posterior pole of the eye. Methods: The acetylsalicylic acid was mixed in silicone oil to a concentration of 1.67 mg/ml. After vitrectomy, 15 NZW rabbits received an intravitreal injection of acetylsalicylic acid/silicone oil suspension. Clinical examination pre- and postoperative electroretinography (ERG) and histology were performed. The pharmacokinetics of the distribution of salicylic acid were determined by HPLC analysis at 6 hours, 24 hours and 5 days in optic nerve, retina, choroid, vitreous, and blood. Results: Clinical examination and histology revealed no adverse effects or signs of toxicity. The ERGs showed no significant difference between the pre- and postoperative results. The salicylic concentrations demonstrated peak values in the residual vitreous (640.0 μg/ml), choroid (446.0 ng/mg) and retina (281.3 ng/mg) at 6 hours. At 24 hours, the salicylic acid concentration decreased to 20.9 μg/ml in the residual vitreous and to 38.5 ng/mg in the retina. At 5 days the retinal level was still 48.1 ng/mg. Discussion: Delivery of acetylsalicylic acid by intravitreal administration of loaded silicone oil is a safe method and results in high concentrations of salicylic acid in the posterior segment of the eye while maintaining low blood levels.
Translated title of the contribution | Intravitreal delivery of acetylsalicylic acid by silicone oil |
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Original language | German |
Pages (from-to) | 194-201 |
Number of pages | 8 |
Journal | Spektrum der Augenheilkunde |
Volume | 15 |
Issue number | 5 |
DOIs | |
State | Published - 2001 |
Keywords
- Acetysalicylic acid
- Drug-transfer
- Pharmacokinetics
- Safety
- Silicone oil
ASJC Scopus subject areas
- Ophthalmology