Intravitreale applikation von azetylsalizylsäure mittels silikonöltamponade

Translated title of the contribution: Intravitreal delivery of acetylsalicylic acid by silicone oil

Martina T. Kralinger, D. Hamasaki, G. F. Kieselbach, Monika Voigt, J. M. Parel

Research output: Contribution to journalArticle

Abstract

Delivery of acetylsalicylic acid by intravitreal silicone oil was investigated for safety and for its pharmacokinetics in the posterior pole of the eye. Methods: The acetylsalicylic acid was mixed in silicone oil to a concentration of 1.67 mg/ml. After vitrectomy, 15 NZW rabbits received an intravitreal injection of acetylsalicylic acid/silicone oil suspension. Clinical examination pre- and postoperative electroretinography (ERG) and histology were performed. The pharmacokinetics of the distribution of salicylic acid were determined by HPLC analysis at 6 hours, 24 hours and 5 days in optic nerve, retina, choroid, vitreous, and blood. Results: Clinical examination and histology revealed no adverse effects or signs of toxicity. The ERGs showed no significant difference between the pre- and postoperative results. The salicylic concentrations demonstrated peak values in the residual vitreous (640.0 μg/ml), choroid (446.0 ng/mg) and retina (281.3 ng/mg) at 6 hours. At 24 hours, the salicylic acid concentration decreased to 20.9 μg/ml in the residual vitreous and to 38.5 ng/mg in the retina. At 5 days the retinal level was still 48.1 ng/mg. Discussion: Delivery of acetylsalicylic acid by intravitreal administration of loaded silicone oil is a safe method and results in high concentrations of salicylic acid in the posterior segment of the eye while maintaining low blood levels.

Original languageGerman
Pages (from-to)194-201
Number of pages8
JournalSpektrum der Augenheilkunde
Volume15
Issue number5
DOIs
StatePublished - Jan 1 2001

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Keywords

  • Acetysalicylic acid
  • Drug-transfer
  • Pharmacokinetics
  • Safety
  • Silicone oil

ASJC Scopus subject areas

  • Ophthalmology

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