Intravitreale applikation von azetylsalizylsäure mittels silikonöltamponade

Translated title of the contribution: Intravitreal delivery of acetylsalicylic acid by silicone oil

Martina T. Kralinger, D. Hamasaki, G. F. Kieselbach, Monika Voigt, J. M. Parel

Research output: Contribution to journalArticlepeer-review

Abstract

Delivery of acetylsalicylic acid by intravitreal silicone oil was investigated for safety and for its pharmacokinetics in the posterior pole of the eye. Methods: The acetylsalicylic acid was mixed in silicone oil to a concentration of 1.67 mg/ml. After vitrectomy, 15 NZW rabbits received an intravitreal injection of acetylsalicylic acid/silicone oil suspension. Clinical examination pre- and postoperative electroretinography (ERG) and histology were performed. The pharmacokinetics of the distribution of salicylic acid were determined by HPLC analysis at 6 hours, 24 hours and 5 days in optic nerve, retina, choroid, vitreous, and blood. Results: Clinical examination and histology revealed no adverse effects or signs of toxicity. The ERGs showed no significant difference between the pre- and postoperative results. The salicylic concentrations demonstrated peak values in the residual vitreous (640.0 μg/ml), choroid (446.0 ng/mg) and retina (281.3 ng/mg) at 6 hours. At 24 hours, the salicylic acid concentration decreased to 20.9 μg/ml in the residual vitreous and to 38.5 ng/mg in the retina. At 5 days the retinal level was still 48.1 ng/mg. Discussion: Delivery of acetylsalicylic acid by intravitreal administration of loaded silicone oil is a safe method and results in high concentrations of salicylic acid in the posterior segment of the eye while maintaining low blood levels.

Translated title of the contributionIntravitreal delivery of acetylsalicylic acid by silicone oil
Original languageGerman
Pages (from-to)194-201
Number of pages8
JournalSpektrum der Augenheilkunde
Volume15
Issue number5
DOIs
StatePublished - Jan 1 2001

Keywords

  • Acetysalicylic acid
  • Drug-transfer
  • Pharmacokinetics
  • Safety
  • Silicone oil

ASJC Scopus subject areas

  • Ophthalmology

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