Intravenous thrombolytic therapy for patients with ventricular assist device thrombosis: An attempt to avoid reoperation

Beth T. Webber, Anthony L. Panos, Yiliam Rodriguez

Research output: Contribution to journalArticle

7 Scopus citations


A growing number of patients are undergoing prolonged management of advanced heart failure with the use of continuous flow left ventricular assist devices (LVADs). Subsequently, an increasing number of patients are presenting with complications associated with these devices. Based on an analysis of three major LVAD institutions, the number of patients developing LVAD pump thrombosis may be much higher than originally projected. [1],[2] The management of this highly feared complication continues to be challenging, as the population of LVAD patients is very heterogeneous and heavily burdened with comorbidities. The standard protocol of increasing anticoagulation may fail to achieve successful resolution of thrombus. Difficulty and poor prognosis may make reoperation less than desirable. Here, we present a case of successful thrombolysis following intravenous administration of tissue plasminogen activator in the Intensive Care Unit setting.

Original languageEnglish (US)
Pages (from-to)192-196
Number of pages5
JournalAnnals of Cardiac Anaesthesia
Issue number1
StatePublished - Jan 1 2016



  • Left ventricular assist devices thrombosis
  • Thrombolytic therapy
  • Ventricular assist device

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Cardiology and Cardiovascular Medicine

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