Intrathecal synthesis of anti-sulfatide IgG is associated with peripheral nerve disease in acquired immunodeficiency syndrome

Rita De Gasperi, Miguel Angel Gama Sosa, Roberto Patarca, Stefania Battistini, Michele R. Lamoreux, Srinivasa Raghavan, Neil W. Kowall, Karen Harrington Smith, Mary Ann Fletcher, Edwin H. Kolodny

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Peripheral nervous system involvement in the acquired immunodeficiency syndrome (AIDS) can take the form of an acute or chronic inflammatory demyelinating polyneuropathy, polyradiculopathy, mononeuropathy multiplex, or autonomic neuropathy. There is no widely held consensus on the etiology of PNS or other neurological complications associated with HIV infection. We report here that PNS disease in HIV-infected individuals is associated with intrathecal synthesis of an antibody directed against sulfatide, a major component of myelin. The anti-sulfatide antibody is also present nonspecifically in serum. The antibody requires the presence of the 3-O- sulfogalactosyl residue for binding and recognizes preferentially the hydroxy fatty acid-containing form of sulfatide. Anti-sulfatide antibodies are therefore one of the humoral factors responsible for demyelinating diseases in AIDS patients.

Original languageEnglish (US)
Pages (from-to)205-211
Number of pages7
JournalAIDS research and human retroviruses
Volume12
Issue number3
DOIs
StatePublished - Feb 10 1996

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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