Intraorbital Optic Nerve and Experimental Optic Neuritis: Correlation of Fat Suppression Magnetic Resonance Imaging and Electron Microscopy

John Guy, Jeffrey Fitzsimmons, E. Ann Ellis, Barbara Beck, Anthony Mancuso

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

To provide magnetic resonance imaging (MRI)-ultrastructural correlations of demyelinating lesions of the intraorbital optic nerve, the authors performed gadolinium-enhanced/T2-weighted fat-suppressed MRI and transmission electron microscopy of the optic nerves of animals with experimental allergic encephalomyelitis. Gadolinium enhancement of the optic nerve adjacent to the globe was seen on fat-suppressed T1-weighted MRI as early as 3 days after antigenic sensitization, increased in severity involving longer segments of nerve at 10 to 14 days, and persisted at 30 days. Gadolinium enhancement preceded T2-weighted signal aberrations. Ultrastructural evaluation of the intraorbital nerve revealed: (1) expansion of the extracellular space and inflammatory infiltrate that correlated with the intensity of gadolinium enhancement; (2) the degree of demyelination correlated with T2-weighted signal aberrations; (3) as deduced from gadolinium enhancement and T2 signal aberrations, breakdown of the blood- brain barrier preceded widespread demyelination; (4) lesions appeared to start at the optic nerve insertion into the globe and then progress toward the orbital apex.

Original languageEnglish (US)
Pages (from-to)720-725
Number of pages6
JournalOphthalmology
Volume99
Issue number5
DOIs
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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