Intraoperative Parathormone Monitoring Mitigates Age-Related Variability in Targeted Parathyroidectomy for Patients with Primary Hyperparathyroidism

Brian Bishop, Bo Wang, Punam P. Parikh, John Lew

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Preoperative parathyroid localization studies, namely, sestamibi (MIBI) and surgeon-performed ultrasound (SUS), are commonly used for targeted parathyroidectomy (PTX) with intraoperative parathormone monitoring (IPM) in patients with primary hyperparathyroidism (pHPT). This study examined age-related variability in abnormal parathyroid gland localization for targeted PTX and the value of IPM across age groups. Methods: A retrospective review examined prospectively collected data of 833 patients who underwent targeted PTX guided by IPM. The patients were stratified into three age groups as follows: younger [73 years; mean +1 SD) based on an age distribution curve for pHPT. The accuracy, sensitivity, and positive predictive value (PPV) for MIBI, SUS, and IPM were analyzed and compared among age groups. Operative success was defined as eucalcemia for 6 months or longer after PTX, and operative failure was defined as elevated calcium and PTH levels within 6 months after PTX. Results: Of the 833 patients, the youngest group had the highest accuracy and sensitivity for MIBI, SUS, and IPM compared with the older groups (p 

Original languageEnglish (US)
Pages (from-to)655-661
Number of pages7
JournalAnnals of Surgical Oncology
Volume22
DOIs
StatePublished - Dec 1 2015

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Intraoperative Monitoring
Parathyroidectomy
Primary Hyperparathyroidism
Parathyroid Hormone
Age Groups
Parathyroid Glands
Age Distribution
Calcium
Surgeons

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Intraoperative Parathormone Monitoring Mitigates Age-Related Variability in Targeted Parathyroidectomy for Patients with Primary Hyperparathyroidism. / Bishop, Brian; Wang, Bo; Parikh, Punam P.; Lew, John.

In: Annals of Surgical Oncology, Vol. 22, 01.12.2015, p. 655-661.

Research output: Contribution to journalArticle

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