Intraoperative echographic localization of iodine 125 episcleral radioactive plaques for posterior uveal melanoma

J. William Harbour, Timothy G. Murray, Sandra Frazier Byrne, J. Randall Hughes, E. Kym Gendron, Fiona J. Ehlies, Arnold Markoe

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Purpose: Plaque radiotherapy has been reported to have a higher relapse rate than charged-particle radiotherapy for posteriorly located uveal melanomas, which also are more technically difficult to localize accurately. The authors used intraoperative echography in patients with posterior uveal melanoma to determine the rate of inaccurate localization of iodine 125 (125I) episcleral plaques using standard localization techniques. Methods: The authors reviewed the records of 29 consecutive patients with medium- sized posterior uveal melanomas who underwent 125I episcleral plaque radiotherapy with intraoperative echographic verification of plaque placement. Results: After careful plaque placement using standard localization techniques, 4 of 29 plaques (14%) did not cover at least one tumor margin. All four of these plaques were associated with posterior tumors with at least one margin posterior to the temporal arcades. Two (7%) additional juxtapapillary plaques were displaced away from the sclera by the optic nerve. In all six cases, it was possible to immediately reposition the plaque to achieve coverage of all tumor margins. Conclusions: Placement of 125I episcleral radioactive plaques for posteriorly located uveal melanomas using standard localization techniques occasionally results in suboptimal plaque positioning. Intraoperative echography can identify plaques that are localized poorly and allows immediate adjustment to achieve optimal plaque positioning.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalRetina
Volume16
Issue number2
StatePublished - May 2 1996

Fingerprint

Iodine
Radiotherapy
Ultrasonography
Neoplasms
Sclera
Optic Nerve
Recurrence
Uveal melanoma

Keywords

  • echography
  • plaque radiotherapy
  • posterior uveal melanoma
  • ultrasonography

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

William Harbour, J., Murray, T. G., Byrne, S. F., Randall Hughes, J., Kym Gendron, E., Ehlies, F. J., & Markoe, A. (1996). Intraoperative echographic localization of iodine 125 episcleral radioactive plaques for posterior uveal melanoma. Retina, 16(2), 129-134.

Intraoperative echographic localization of iodine 125 episcleral radioactive plaques for posterior uveal melanoma. / William Harbour, J.; Murray, Timothy G.; Byrne, Sandra Frazier; Randall Hughes, J.; Kym Gendron, E.; Ehlies, Fiona J.; Markoe, Arnold.

In: Retina, Vol. 16, No. 2, 02.05.1996, p. 129-134.

Research output: Contribution to journalArticle

William Harbour, J, Murray, TG, Byrne, SF, Randall Hughes, J, Kym Gendron, E, Ehlies, FJ & Markoe, A 1996, 'Intraoperative echographic localization of iodine 125 episcleral radioactive plaques for posterior uveal melanoma', Retina, vol. 16, no. 2, pp. 129-134.
William Harbour J, Murray TG, Byrne SF, Randall Hughes J, Kym Gendron E, Ehlies FJ et al. Intraoperative echographic localization of iodine 125 episcleral radioactive plaques for posterior uveal melanoma. Retina. 1996 May 2;16(2):129-134.
William Harbour, J. ; Murray, Timothy G. ; Byrne, Sandra Frazier ; Randall Hughes, J. ; Kym Gendron, E. ; Ehlies, Fiona J. ; Markoe, Arnold. / Intraoperative echographic localization of iodine 125 episcleral radioactive plaques for posterior uveal melanoma. In: Retina. 1996 ; Vol. 16, No. 2. pp. 129-134.
@article{c85b52593cd542a3966980b5d86b0148,
title = "Intraoperative echographic localization of iodine 125 episcleral radioactive plaques for posterior uveal melanoma",
abstract = "Purpose: Plaque radiotherapy has been reported to have a higher relapse rate than charged-particle radiotherapy for posteriorly located uveal melanomas, which also are more technically difficult to localize accurately. The authors used intraoperative echography in patients with posterior uveal melanoma to determine the rate of inaccurate localization of iodine 125 (125I) episcleral plaques using standard localization techniques. Methods: The authors reviewed the records of 29 consecutive patients with medium- sized posterior uveal melanomas who underwent 125I episcleral plaque radiotherapy with intraoperative echographic verification of plaque placement. Results: After careful plaque placement using standard localization techniques, 4 of 29 plaques (14{\%}) did not cover at least one tumor margin. All four of these plaques were associated with posterior tumors with at least one margin posterior to the temporal arcades. Two (7{\%}) additional juxtapapillary plaques were displaced away from the sclera by the optic nerve. In all six cases, it was possible to immediately reposition the plaque to achieve coverage of all tumor margins. Conclusions: Placement of 125I episcleral radioactive plaques for posteriorly located uveal melanomas using standard localization techniques occasionally results in suboptimal plaque positioning. Intraoperative echography can identify plaques that are localized poorly and allows immediate adjustment to achieve optimal plaque positioning.",
keywords = "echography, plaque radiotherapy, posterior uveal melanoma, ultrasonography",
author = "{William Harbour}, J. and Murray, {Timothy G.} and Byrne, {Sandra Frazier} and {Randall Hughes}, J. and {Kym Gendron}, E. and Ehlies, {Fiona J.} and Arnold Markoe",
year = "1996",
month = "5",
day = "2",
language = "English",
volume = "16",
pages = "129--134",
journal = "Retina",
issn = "0275-004X",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Intraoperative echographic localization of iodine 125 episcleral radioactive plaques for posterior uveal melanoma

AU - William Harbour, J.

AU - Murray, Timothy G.

AU - Byrne, Sandra Frazier

AU - Randall Hughes, J.

AU - Kym Gendron, E.

AU - Ehlies, Fiona J.

AU - Markoe, Arnold

PY - 1996/5/2

Y1 - 1996/5/2

N2 - Purpose: Plaque radiotherapy has been reported to have a higher relapse rate than charged-particle radiotherapy for posteriorly located uveal melanomas, which also are more technically difficult to localize accurately. The authors used intraoperative echography in patients with posterior uveal melanoma to determine the rate of inaccurate localization of iodine 125 (125I) episcleral plaques using standard localization techniques. Methods: The authors reviewed the records of 29 consecutive patients with medium- sized posterior uveal melanomas who underwent 125I episcleral plaque radiotherapy with intraoperative echographic verification of plaque placement. Results: After careful plaque placement using standard localization techniques, 4 of 29 plaques (14%) did not cover at least one tumor margin. All four of these plaques were associated with posterior tumors with at least one margin posterior to the temporal arcades. Two (7%) additional juxtapapillary plaques were displaced away from the sclera by the optic nerve. In all six cases, it was possible to immediately reposition the plaque to achieve coverage of all tumor margins. Conclusions: Placement of 125I episcleral radioactive plaques for posteriorly located uveal melanomas using standard localization techniques occasionally results in suboptimal plaque positioning. Intraoperative echography can identify plaques that are localized poorly and allows immediate adjustment to achieve optimal plaque positioning.

AB - Purpose: Plaque radiotherapy has been reported to have a higher relapse rate than charged-particle radiotherapy for posteriorly located uveal melanomas, which also are more technically difficult to localize accurately. The authors used intraoperative echography in patients with posterior uveal melanoma to determine the rate of inaccurate localization of iodine 125 (125I) episcleral plaques using standard localization techniques. Methods: The authors reviewed the records of 29 consecutive patients with medium- sized posterior uveal melanomas who underwent 125I episcleral plaque radiotherapy with intraoperative echographic verification of plaque placement. Results: After careful plaque placement using standard localization techniques, 4 of 29 plaques (14%) did not cover at least one tumor margin. All four of these plaques were associated with posterior tumors with at least one margin posterior to the temporal arcades. Two (7%) additional juxtapapillary plaques were displaced away from the sclera by the optic nerve. In all six cases, it was possible to immediately reposition the plaque to achieve coverage of all tumor margins. Conclusions: Placement of 125I episcleral radioactive plaques for posteriorly located uveal melanomas using standard localization techniques occasionally results in suboptimal plaque positioning. Intraoperative echography can identify plaques that are localized poorly and allows immediate adjustment to achieve optimal plaque positioning.

KW - echography

KW - plaque radiotherapy

KW - posterior uveal melanoma

KW - ultrasonography

UR - http://www.scopus.com/inward/record.url?scp=9244233310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9244233310&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 129

EP - 134

JO - Retina

JF - Retina

SN - 0275-004X

IS - 2

ER -