Intraocular tamponade duration and success of macular hole surgery

John T. Thompson, William E. Smiddy, Bert M. Glaser, Raymond N. Sjaarda, Harry W. Flynn

Research output: Contribution to journalArticle

131 Scopus citations

Abstract

Purpose: The authors compare the success of macular hole surgery with a short duration tamponade using 5% perfluoropropane (C 3F 8), intermediate duration tamponade using 10% C 3F 8, or a long duration tamponade using 16% C 3F 8 in a prospective consecutive clinical trial at two institutions. Methods: Vitrectomy and fluid-gas exchange was performed in 29 eyes treated with 5% C 3F 8 and 1 week of prone positioning, 30 eyes treated with 10% C 3F 8 and 2 weeks of prone positioning, and 90 eyes treated with 16% C 3F 8 and 2 weeks of prone positioning 90% of time, followed by 2 weeks of prone positioning 50% of time. Results: The macular hole was closed successfully in 19 of 29 eyes (65.6%) treated with 5% C 3F 8, 19 of 30 eyes (63.3%) treated with 10% C 3F 8, and 85 of 90 eyes (94.4%) treated with 16% C 3F 8 at 3 months (P = 0.00017 for 5% vs. 16% C 3F 8, P = 0.00006 for 10% vs. 16% C 3F 8). The visual acuity improvements measured by refraction using the Early Treatment Diabetic Retinopathy Study (ETDRS) acuity charts paralleled the success of macular hole closure. The acuity improved a mean improvement of + 9.6 ETDRS letters for eyes treated with 5% C 3F 8, + 6.4 ETDRS letters for eyes treated with 10% C 3F 8, and + 13.1 ETDRS letters in eyes treated with 16% C 3F 8. Conclusions: A long duration intraocular gas tamponade with 16% C 3F 8 gives a substantially higher success rate for macular hole surgery than a short (5% C 3F 8) or intermediate duration (10% C 3F 8) intraocular gas tamponade.

Original languageEnglish (US)
Pages (from-to)373-382
Number of pages10
JournalRetina
Volume16
Issue number5
DOIs
StatePublished - Nov 13 1996

Keywords

  • intraocular gas
  • intraocular gas tamponade
  • macular hole
  • perfluoropropane
  • transforming growth factor beta-2
  • vitrectomy

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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