Intraocular Penetration of Cytosine Arabinoside Following Subconjunctival Administration in Primates

Michael L. Graham, David L. Cheo, William E. Smiddy, Andrew P. Schachat

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Cytosine arabinoside was administered subconjunctivally to three monkeys. Blood, aqueous, and vitreous specimens were collected after 30 minutes, 1 hour, 2 hours, and 3 hours. Intraocular drug concentrations appeared stable or increasing over this time period while intravenous levels were relatively low. The results of this study suggest that therapeutic intraocular concentrations of cytosine arabinoside are obtained following subconjunctival administration in primates with lower, nontoxic intravenous levels during this time.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
JournalJournal of Ocular Pharmacology
Volume5
Issue number3
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Ophthalmology
  • Pharmacology
  • Pharmacology (medical)

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