Intraocular Penetration of Cytosine Arabinoside Following Intravenous Administration in Primates

William E. Smiddy, Michael L. Graham, David L. Cheo, Andrew P. Schachat

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Cytosine arabinoside was administered intravenously to three monkeys. Blood, aqueous, and vitreous specimens were collected after 30 minutes, 1 hour, 2 hours, and 3 hours. Intraocular and intravenous drug concentrations were comparable at all time points, at levels likely to be effective against human tumors. This study suggests that therapeutic intraocular concentrations of cytosine, arabinoside are attained following intravenous administration in primates.

Original languageEnglish (US)
Pages (from-to)133-136
Number of pages4
JournalJournal of Ocular Pharmacology and Therapeutics
Volume4
Issue number2
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Pharmacology
  • Pharmacology (medical)

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