Abstract
Cytosine arabinoside was administered intravenously to three monkeys. Blood, aqueous, and vitreous specimens were collected after 30 minutes, 1 hour, 2 hours, and 3 hours. Intraocular and intravenous drug concentrations were comparable at all time points, at levels likely to be effective against human tumors. This study suggests that therapeutic intraocular concentrations of cytosine, arabinoside are attained following intravenous administration in primates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 133-136 |
| Number of pages | 4 |
| Journal | Journal of Ocular Pharmacology and Therapeutics |
| Volume | 4 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1988 |
| Externally published | Yes |
ASJC Scopus subject areas
- Ophthalmology
- Pharmacology
- Pharmacology (medical)
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Cite this
Smiddy, W. E., Graham, M. L., Cheo, D. L., & Schachat, A. P. (1988). Intraocular Penetration of Cytosine Arabinoside Following Intravenous Administration in Primates. Journal of Ocular Pharmacology and Therapeutics, 4(2), 133-136. https://doi.org/10.1089/jop.1988.4.133