Abstract
Cytosine arabinoside was administered intravenously to three monkeys. Blood, aqueous, and vitreous specimens were collected after 30 minutes, 1 hour, 2 hours, and 3 hours. Intraocular and intravenous drug concentrations were comparable at all time points, at levels likely to be effective against human tumors. This study suggests that therapeutic intraocular concentrations of cytosine, arabinoside are attained following intravenous administration in primates.
| Original language | English |
|---|---|
| Pages (from-to) | 133-136 |
| Number of pages | 4 |
| Journal | Journal of Ocular Pharmacology |
| Volume | 4 |
| Issue number | 2 |
| State | Published - Jan 1 1988 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Ophthalmology
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Intraocular penetration of cytosine arabinoside following intravenous administration in primates. / Smiddy, William E; Graham, M. L.; Cheo, D. L.; Schachat, A. P.
In: Journal of Ocular Pharmacology, Vol. 4, No. 2, 01.01.1988, p. 133-136.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intraocular penetration of cytosine arabinoside following intravenous administration in primates
AU - Smiddy, William E
AU - Graham, M. L.
AU - Cheo, D. L.
AU - Schachat, A. P.
PY - 1988/1/1
Y1 - 1988/1/1
N2 - Cytosine arabinoside was administered intravenously to three monkeys. Blood, aqueous, and vitreous specimens were collected after 30 minutes, 1 hour, 2 hours, and 3 hours. Intraocular and intravenous drug concentrations were comparable at all time points, at levels likely to be effective against human tumors. This study suggests that therapeutic intraocular concentrations of cytosine, arabinoside are attained following intravenous administration in primates.
AB - Cytosine arabinoside was administered intravenously to three monkeys. Blood, aqueous, and vitreous specimens were collected after 30 minutes, 1 hour, 2 hours, and 3 hours. Intraocular and intravenous drug concentrations were comparable at all time points, at levels likely to be effective against human tumors. This study suggests that therapeutic intraocular concentrations of cytosine, arabinoside are attained following intravenous administration in primates.
UR - http://www.scopus.com/inward/record.url?scp=0023813747&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023813747&partnerID=8YFLogxK
M3 - Article
C2 - 3171337
AN - SCOPUS:0023813747
VL - 4
SP - 133
EP - 136
JO - Journal of Ocular Pharmacology and Therapeutics
JF - Journal of Ocular Pharmacology and Therapeutics
SN - 1080-7683
IS - 2
ER -