Intraocular HIV-1-specific IgG synthesis in a patient with CMV retinitis.

R. D. Dix, L. Resnick, William W Culbertson, Gordon Dickinson, E. Fisher, M. Saenz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A sight-threatening cytomegalovirus (CMV) retinitis is often associated with acquired immune deficiency syndrome (AIDS). We report the detection and quantitation of antibodies specific for CMV and human immunodeficiency virus type 1 (HIV-1) in the vitreous fluid and serum of an AIDS patient suffering from bilateral CMV retinitis. The ratio of the concentrations of HIV-1-specific immunoglobulin G (IgG) to total IgG in the vitreous fluid was found to be higher than that of the peripheral blood, indicating a local production of HIV-1-specific IgG synthesis within the ocular compartment. In contrast, CMV-specific IgG levels in serum were found to be higher than that of vitreous fluid, indicating an intact blood-ocular barrier. CMV and HIV were also isolated from the ocular tissues of this patient. These findings are consistent with the hypothesis that CMV retinitis may be associated with HIV-1 infection of the ocular tissues, which evokes an HIV-1-specific humoral immune response locally within the ocular compartment.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalRegional immunology
Volume2
Issue number1
StatePublished - Jan 1 1989

Fingerprint

Cytomegalovirus Retinitis
HIV-1
Immunoglobulin G
Cytomegalovirus
Acquired Immunodeficiency Syndrome
Virus Diseases
Humoral Immunity
Serum
HIV
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Intraocular HIV-1-specific IgG synthesis in a patient with CMV retinitis. / Dix, R. D.; Resnick, L.; Culbertson, William W; Dickinson, Gordon; Fisher, E.; Saenz, M.

In: Regional immunology, Vol. 2, No. 1, 01.01.1989, p. 1-6.

Research output: Contribution to journalArticle

@article{a8f704041bb842c891f300530a60c487,
title = "Intraocular HIV-1-specific IgG synthesis in a patient with CMV retinitis.",
abstract = "A sight-threatening cytomegalovirus (CMV) retinitis is often associated with acquired immune deficiency syndrome (AIDS). We report the detection and quantitation of antibodies specific for CMV and human immunodeficiency virus type 1 (HIV-1) in the vitreous fluid and serum of an AIDS patient suffering from bilateral CMV retinitis. The ratio of the concentrations of HIV-1-specific immunoglobulin G (IgG) to total IgG in the vitreous fluid was found to be higher than that of the peripheral blood, indicating a local production of HIV-1-specific IgG synthesis within the ocular compartment. In contrast, CMV-specific IgG levels in serum were found to be higher than that of vitreous fluid, indicating an intact blood-ocular barrier. CMV and HIV were also isolated from the ocular tissues of this patient. These findings are consistent with the hypothesis that CMV retinitis may be associated with HIV-1 infection of the ocular tissues, which evokes an HIV-1-specific humoral immune response locally within the ocular compartment.",
author = "Dix, {R. D.} and L. Resnick and Culbertson, {William W} and Gordon Dickinson and E. Fisher and M. Saenz",
year = "1989",
month = "1",
day = "1",
language = "English",
volume = "2",
pages = "1--6",
journal = "Regional immunology",
issn = "0896-0623",
number = "1",

}

TY - JOUR

T1 - Intraocular HIV-1-specific IgG synthesis in a patient with CMV retinitis.

AU - Dix, R. D.

AU - Resnick, L.

AU - Culbertson, William W

AU - Dickinson, Gordon

AU - Fisher, E.

AU - Saenz, M.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - A sight-threatening cytomegalovirus (CMV) retinitis is often associated with acquired immune deficiency syndrome (AIDS). We report the detection and quantitation of antibodies specific for CMV and human immunodeficiency virus type 1 (HIV-1) in the vitreous fluid and serum of an AIDS patient suffering from bilateral CMV retinitis. The ratio of the concentrations of HIV-1-specific immunoglobulin G (IgG) to total IgG in the vitreous fluid was found to be higher than that of the peripheral blood, indicating a local production of HIV-1-specific IgG synthesis within the ocular compartment. In contrast, CMV-specific IgG levels in serum were found to be higher than that of vitreous fluid, indicating an intact blood-ocular barrier. CMV and HIV were also isolated from the ocular tissues of this patient. These findings are consistent with the hypothesis that CMV retinitis may be associated with HIV-1 infection of the ocular tissues, which evokes an HIV-1-specific humoral immune response locally within the ocular compartment.

AB - A sight-threatening cytomegalovirus (CMV) retinitis is often associated with acquired immune deficiency syndrome (AIDS). We report the detection and quantitation of antibodies specific for CMV and human immunodeficiency virus type 1 (HIV-1) in the vitreous fluid and serum of an AIDS patient suffering from bilateral CMV retinitis. The ratio of the concentrations of HIV-1-specific immunoglobulin G (IgG) to total IgG in the vitreous fluid was found to be higher than that of the peripheral blood, indicating a local production of HIV-1-specific IgG synthesis within the ocular compartment. In contrast, CMV-specific IgG levels in serum were found to be higher than that of vitreous fluid, indicating an intact blood-ocular barrier. CMV and HIV were also isolated from the ocular tissues of this patient. These findings are consistent with the hypothesis that CMV retinitis may be associated with HIV-1 infection of the ocular tissues, which evokes an HIV-1-specific humoral immune response locally within the ocular compartment.

UR - http://www.scopus.com/inward/record.url?scp=0024305719&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024305719&partnerID=8YFLogxK

M3 - Article

C2 - 2561959

AN - SCOPUS:0024305719

VL - 2

SP - 1

EP - 6

JO - Regional immunology

JF - Regional immunology

SN - 0896-0623

IS - 1

ER -