Intraocular dissemination of uveal melanoma cells following radiotherapy: Evolving management over the past decade

Manuel Paez-Escamilla, Scott D. Walter, Amir Mohsenin, Christina L. Decatur, George J. Harocopos, Sander Dubovy, J. William Harbour

Research output: Contribution to journalArticle

Abstract

BACKGROUND AND OBJECTIVE: To describe the presentation and the authors' evolving management strategy for intraocular dissemination of uveal melanoma cells following radiotherapy during the past decade. PATIENTS AND METHODS: Patients with uveal melanoma who developed intraocular dissemination of pigmented cells following radiotherapy. Histopathology was available in two cases. RESULTS: Four patients underwent treatment for progressive intraocular dissemination of uveal melanoma cells at 9 to 41 months following I-125 plaque radiotherapy (three patients) or proton beam radiotherapy (one patient). Treatments included primary enucleation (one patient), vitrectomy followed later by enucleation (one patient), and vitrectomy followed by intravitreal chemotherapy (two patients). Enucleated eyes demonstrated diffuse invasion of intraocular tissues by viable melanoma cells. No patient has developed systemic metastasis to date. CONCLUSIONS: Intraocular dissemination of pigmented cells following radiotherapy for uveal melanoma should raise suspicion for viable invasive melanoma cells. Prompt vitrectomy with intravitreal chemotherapy can be effective in avoiding enucleation in selected cases.

Original languageEnglish (US)
Pages (from-to)573-579
Number of pages7
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume50
Issue number9
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

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Radiotherapy
Vitrectomy
Melanoma
Drug Therapy
Uveal melanoma
Protons
Neoplasm Metastasis
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

Cite this

Intraocular dissemination of uveal melanoma cells following radiotherapy : Evolving management over the past decade. / Paez-Escamilla, Manuel; Walter, Scott D.; Mohsenin, Amir; Decatur, Christina L.; Harocopos, George J.; Dubovy, Sander; Harbour, J. William.

In: Ophthalmic Surgery Lasers and Imaging Retina, Vol. 50, No. 9, 01.01.2019, p. 573-579.

Research output: Contribution to journalArticle

Paez-Escamilla, Manuel ; Walter, Scott D. ; Mohsenin, Amir ; Decatur, Christina L. ; Harocopos, George J. ; Dubovy, Sander ; Harbour, J. William. / Intraocular dissemination of uveal melanoma cells following radiotherapy : Evolving management over the past decade. In: Ophthalmic Surgery Lasers and Imaging Retina. 2019 ; Vol. 50, No. 9. pp. 573-579.
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