Intraneuronal APOE in human visual cortical areas reflects the staging, of Alzheimer disease pathology

Gillian Einstein, Vikas Patel, Phillip Bautista, Michelle Kenna, Leah Melone, Robyn Fader, Kris Karson, Stephanie Mann, Ann M. Saunders, Christine Hulette, Deborah Mash, Allen D. Roses, Donald E. Schmechel

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Alzheimer disease (AD) is marked by progressive loss of cortical neurons with associated cognitive decline. Multiple genetic and environmental factors likely contribute to this progressive loss. Such genetic factors include thee polymorphic locus (APOE) that encodes apolipoprotein E (apoE). In order to investigate a possible correspondence between cellular localization of apoE and the neuropathology of AD, we examined the distribution of apoE- immunoreactive neurons in visual cortical areas with different apparent susceptibility to AD neuropathology (areas 17-primary sensory, 18-secondary sensory, and inferior temporal-association cortex) at different stages of AD pathology as described by Braak and Braak. We found that intraneuronal apoE was present at all these stages, however, only in visual cortical regions known to be vulnerable to AD. In the late stages, the laminar distribution of apoE-immunoreactivity matched the distribution of other markers of Ap pathology, especially modified tau. These data support previous findings that intraneuronal apoE in neocortex is aged, nondemented controls and demonstrate that it may be more common in regions at risk for AD pathology. Thus, intraneuronal accumulation of apoE may be an attribute of cortical neurons that are more vulnerable to age-relate injury with the presence of apoE antedating the classical indices of late-onset AD pathology.

Original languageEnglish (US)
Pages (from-to)1190-1201
Number of pages12
JournalJournal of Neuropathology and Experimental Neurology
Volume57
Issue number12
DOIs
StatePublished - Dec 1998

Keywords

  • Aging
  • Alzheimer disease
  • Association cortex
  • Neuropathology
  • Pyramidal neurons
  • Tau

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

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    Einstein, G., Patel, V., Bautista, P., Kenna, M., Melone, L., Fader, R., Karson, K., Mann, S., Saunders, A. M., Hulette, C., Mash, D., Roses, A. D., & Schmechel, D. E. (1998). Intraneuronal APOE in human visual cortical areas reflects the staging, of Alzheimer disease pathology. Journal of Neuropathology and Experimental Neurology, 57(12), 1190-1201. https://doi.org/10.1097/00005072-199812000-00011