Abstract
The axial aqua bound copper(ii) complex [Cu(dpq)2(H2O)](ClO4)2, having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of 5.58 ± 0.4 h−1and a rate enhancement of 1.55 × 108.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 697-698 |
| Number of pages | 2 |
| Journal | Journal of the Chemical Society. Dalton Transactions |
| Volume | 4 |
| Issue number | 5 |
| DOIs | |
| State | Published - Feb 20 2004 |
Keywords
- Bioinorganic chemistry
- Copper
- Dipyridoquinoxaline
- Dna
- Hydrolysis
ASJC Scopus subject areas
- Chemistry(all)
Fingerprint Dive into the research topics of 'Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis(dipyridoquinoxaline)copper(ii) complex'. Together they form a unique fingerprint.
Cite this
Dhar, S., Reddy, P. A. N., & Chakravarty, A. R. (2004). Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis(dipyridoquinoxaline)copper(ii) complex. Journal of the Chemical Society. Dalton Transactions, 4(5), 697-698. https://doi.org/10.1039/b401383b