Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis(dipyridoquinoxaline)copper(ii) complex

Shanta Dhar, Pattubala A.N. Reddy, Akhil R. Chakravarty

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

The axial aqua bound copper(ii) complex [Cu(dpq)2(H2O)](ClO4)2, having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of 5.58 ± 0.4 h−1and a rate enhancement of 1.55 × 108.

Original languageEnglish (US)
Pages (from-to)697-698
Number of pages2
JournalJournal of the Chemical Society. Dalton Transactions
Volume4
Issue number5
DOIs
StatePublished - Feb 20 2004

Keywords

  • Bioinorganic chemistry
  • Copper
  • Dipyridoquinoxaline
  • Dna
  • Hydrolysis

ASJC Scopus subject areas

  • Chemistry(all)

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