Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis(dipyridoquinoxaline)copper(ii) complex

Shanta Dhar; Pattubala A.N. Reddy; Akhil R. Chakravarty

doi:10.1039/b401383b

Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis(dipyridoquinoxaline)copper(ii) complex

Shanta Dhar, Pattubala A.N. Reddy, Akhil R. Chakravarty

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

The axial aqua bound copper(ii) complex [Cu(dpq)₂(H₂O)](ClO₄)₂, having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of 5.58 ± 0.4 h⁻¹and a rate enhancement of 1.55 × 10⁸.

Original language	English (US)
Pages (from-to)	697-698
Number of pages	2
Journal	Journal of the Chemical Society. Dalton Transactions
Volume	4
Issue number	5
DOIs	https://doi.org/10.1039/b401383b
State	Published - Feb 20 2004
Externally published	Yes

Keywords

Bioinorganic chemistry
Copper
Dipyridoquinoxaline
Dna
Hydrolysis

ASJC Scopus subject areas

Chemistry(all)

Access to Document

10.1039/b401383b

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title = "Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis(dipyridoquinoxaline)copper(ii) complex",

abstract = "The axial aqua bound copper(ii) complex [Cu(dpq)2(H2O)](ClO4)2, having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of 5.58 ± 0.4 h−1and a rate enhancement of 1.55 × 108.",

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AU - Reddy, Pattubala A.N.

AU - Chakravarty, Akhil R.

PY - 2004/2/20

Y1 - 2004/2/20

N2 - The axial aqua bound copper(ii) complex [Cu(dpq)2(H2O)](ClO4)2, having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of 5.58 ± 0.4 h−1and a rate enhancement of 1.55 × 108.

AB - The axial aqua bound copper(ii) complex [Cu(dpq)2(H2O)](ClO4)2, having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of 5.58 ± 0.4 h−1and a rate enhancement of 1.55 × 108.

KW - Bioinorganic chemistry

KW - Copper

KW - Dipyridoquinoxaline

KW - Dna

KW - Hydrolysis

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