Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis-(dipyridoquinoxaline)copper(II) complex

Shanta Dhar; Pattubala A.N. Reddy; Akhil R. Chakravarty

Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis-(dipyridoquinoxaline)copper(II) complex

Shanta Dhar, Pattubala A.N. Reddy, Akhil R. Chakravarty

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article

59 Scopus citations

Abstract

The axial aqua bound copper(II) complex [Cu(dpq)₂-(H₂O)](ClO₄)₂, having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of 5.58 ± 0.4 h^-1 and a rate enhancement of 1.55 × 10⁸.

Original language	English (US)
Pages (from-to)	697-698
Number of pages	2
Journal	Dalton Transactions
Issue number	5
State	Published - Mar 7 2004

Fingerprint

ASJC Scopus subject areas

Inorganic Chemistry

Cite this

Dhar, S., Reddy, P. A. N., & Chakravarty, A. R. (2004). Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis-(dipyridoquinoxaline)copper(II) complex. Dalton Transactions, (5), 697-698.

@article{78009f71a60c45d6a8997167af1f9a0a,

title = "Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis-(dipyridoquinoxaline)copper(II) complex",

abstract = "The axial aqua bound copper(II) complex [Cu(dpq)2-(H2O)](ClO4)2, having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of 5.58 ± 0.4 h-1 and a rate enhancement of 1.55 × 108.",

author = "Shanta Dhar and Reddy, {Pattubala A.N.} and Chakravarty, {Akhil R.}",

year = "2004",

month = mar

day = "7",

language = "English (US)",

pages = "697--698",

journal = "Dalton Transactions",

issn = "1477-9226",

publisher = "Royal Society of Chemistry",

number = "5",

}

TY - JOUR

T1 - Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis-(dipyridoquinoxaline)copper(II) complex

AU - Dhar, Shanta

AU - Reddy, Pattubala A.N.

AU - Chakravarty, Akhil R.

PY - 2004/3/7

Y1 - 2004/3/7

N2 - The axial aqua bound copper(II) complex [Cu(dpq)2-(H2O)](ClO4)2, having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of 5.58 ± 0.4 h-1 and a rate enhancement of 1.55 × 108.

AB - The axial aqua bound copper(II) complex [Cu(dpq)2-(H2O)](ClO4)2, having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of 5.58 ± 0.4 h-1 and a rate enhancement of 1.55 × 108.

UR - http://www.scopus.com/inward/record.url?scp=1642408531&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642408531&partnerID=8YFLogxK

M3 - Article

C2 - 15252488

AN - SCOPUS:1642408531

SP - 697

EP - 698

JO - Dalton Transactions

JF - Dalton Transactions

SN - 1477-9226

IS - 5

ER -

Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis-(dipyridoquinoxaline)copper(II) complex

Abstract

Fingerprint

ASJC Scopus subject areas

Cite this

Access to Document