The axial aqua bound copper(ii) complex [Cu(dpq)2(H2O)](ClO4)2, having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of 5.58 ± 0.4 h−1and a rate enhancement of 1.55 × 108.
|Original language||English (US)|
|Number of pages||2|
|Journal||Journal of the Chemical Society. Dalton Transactions|
|State||Published - Feb 20 2004|
- Bioinorganic chemistry
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