Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis-(dipyridoquinoxaline)copper(II) complex

Shanta Dhar, Pattubala A.N. Reddy, Akhil R. Chakravarty

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Abstract

The axial aqua bound copper(II) complex [Cu(dpq)2-(H2O)](ClO4)2, having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of 5.58 ± 0.4 h-1 and a rate enhancement of 1.55 × 108.

Original languageEnglish (US)
Pages (from-to)697-698
Number of pages2
JournalDalton Transactions
Issue number5
StatePublished - Mar 7 2004

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ASJC Scopus subject areas

  • Inorganic Chemistry

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