Intralymphatic antibiotic delivery for reducing acute prosthetic graft infection

D. L. Foilsom, Dido Franceschi, J. R. Rubin

Research output: Contribution to journalArticle

Abstract

The lymphatic system has been implicated as a source of synthetic graft contamination when grafts are implanted in the presence of a distal septic focus. In previous studies, radical lymphatic excision and ligation were shown to reduce acute graft sepsis. However significant lymphedema precluded its clinical application. The present study was undertaken to evaluate methods for reducint acute graft sepsis while avoiding lymphatic obstructive complications. Twenty dogs were divided into one control and two experimental cohorts. Femoral interposition grafts were placed in each dog. A hind paw septic focus was introduced and therapy included a control (Group I - no therapy), intravenous antibiotics in Group II and intralymphatic antibiotics in Group III. Graft, blood and tissue cultures from each dog were taken at 48 hours. Lymphatic antibiotic therapy resulted in significantly improved graft culture results when compared to the control (p = 0.0003) and intravenously treated animals (p = 0.007). Blood cultures in the intralymphatically treated group were also significantly better (p = 0.003) than the control group.

Original languageEnglish
Pages (from-to)660-663
Number of pages4
JournalJournal of Cardiovascular Surgery
Volume33
Issue number6
StatePublished - Dec 1 1992
Externally publishedYes

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Anti-Bacterial Agents
Transplants
Infection
Dogs
Sepsis
Lymphatic System
Control Groups
Lymphedema
Thigh
Ligation
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Intralymphatic antibiotic delivery for reducing acute prosthetic graft infection. / Foilsom, D. L.; Franceschi, Dido; Rubin, J. R.

In: Journal of Cardiovascular Surgery, Vol. 33, No. 6, 01.12.1992, p. 660-663.

Research output: Contribution to journalArticle

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