Abstract
Objective: We report that intractable early childhood obesity may be associated with severe insulin resistance syndromes (pseudo-Cushing's syndrome and pseudo-acromegaly) and precede polycystic ovary syndrome (PCOS). Study design/Results: Patient 1 had prepubertal obesity followed by early puberty and was diagnosed with pseudo-Cushing's syndrome and insulin resistance at 10.3 years. Oligomenorrhea, androgen excess, and type 2 diabetes mellitus (DM2) emerged at 13.5 years. Patient 2 developed intractable prepubertal obesity followed by atypical true sexual precocity and pseudo-Cushing's syndrome in early childhood. By 11.3 years, oligomenorrhea, androgen excess, and DM2 had appeared. Patient 3 had prepubertal overgrowth in weight and height and was diagnosed with pseudo-acromegaly, menstrual irregularity, androgen excess, and impaired glucose tolerance at 14.3 years of age. Patient 4 had prepubertal overgrowth that evolved into pseudo-acromegaly, insulin resistance, secondary amenorrhea, and androgen excess at 15.6 years. Conclusions: Intractable prepubertal obesity was recognized to culminate in early childhood pseudo-Cushing's syndrome or pseudo-acromegaly, which are manifestations of insulin-resistant hyperinsulinism, and to herald adolescent PCOS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 41-51 |
| Number of pages | 11 |
| Journal | Journal of Pediatric Endocrinology and Metabolism |
| Volume | 20 |
| Issue number | 1 |
| State | Published - Jan 2007 |
| Externally published | Yes |
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Keywords
- Insulin resistance
- Obesity
- Polycystic ovary syndrome
- Precocious puberty
- Pseudo-acromegaly
- Pseudo-Cushing's syndrome
ASJC Scopus subject areas
- Endocrinology
- Pediatrics, Perinatology, and Child Health
Cite this
Intractable early childhood obesity as the initial sign of insulin resistant hyperinsulinism and precursor of polycystic ovary syndrome. / Littlejohn, Elizabeth E.; Weiss, Roy E; Deplewski, Dianne; Edidin, Deborah V.; Rosenfield, Robert.
In: Journal of Pediatric Endocrinology and Metabolism, Vol. 20, No. 1, 01.2007, p. 41-51.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intractable early childhood obesity as the initial sign of insulin resistant hyperinsulinism and precursor of polycystic ovary syndrome
AU - Littlejohn, Elizabeth E.
AU - Weiss, Roy E
AU - Deplewski, Dianne
AU - Edidin, Deborah V.
AU - Rosenfield, Robert
PY - 2007/1
Y1 - 2007/1
N2 - Objective: We report that intractable early childhood obesity may be associated with severe insulin resistance syndromes (pseudo-Cushing's syndrome and pseudo-acromegaly) and precede polycystic ovary syndrome (PCOS). Study design/Results: Patient 1 had prepubertal obesity followed by early puberty and was diagnosed with pseudo-Cushing's syndrome and insulin resistance at 10.3 years. Oligomenorrhea, androgen excess, and type 2 diabetes mellitus (DM2) emerged at 13.5 years. Patient 2 developed intractable prepubertal obesity followed by atypical true sexual precocity and pseudo-Cushing's syndrome in early childhood. By 11.3 years, oligomenorrhea, androgen excess, and DM2 had appeared. Patient 3 had prepubertal overgrowth in weight and height and was diagnosed with pseudo-acromegaly, menstrual irregularity, androgen excess, and impaired glucose tolerance at 14.3 years of age. Patient 4 had prepubertal overgrowth that evolved into pseudo-acromegaly, insulin resistance, secondary amenorrhea, and androgen excess at 15.6 years. Conclusions: Intractable prepubertal obesity was recognized to culminate in early childhood pseudo-Cushing's syndrome or pseudo-acromegaly, which are manifestations of insulin-resistant hyperinsulinism, and to herald adolescent PCOS.
AB - Objective: We report that intractable early childhood obesity may be associated with severe insulin resistance syndromes (pseudo-Cushing's syndrome and pseudo-acromegaly) and precede polycystic ovary syndrome (PCOS). Study design/Results: Patient 1 had prepubertal obesity followed by early puberty and was diagnosed with pseudo-Cushing's syndrome and insulin resistance at 10.3 years. Oligomenorrhea, androgen excess, and type 2 diabetes mellitus (DM2) emerged at 13.5 years. Patient 2 developed intractable prepubertal obesity followed by atypical true sexual precocity and pseudo-Cushing's syndrome in early childhood. By 11.3 years, oligomenorrhea, androgen excess, and DM2 had appeared. Patient 3 had prepubertal overgrowth in weight and height and was diagnosed with pseudo-acromegaly, menstrual irregularity, androgen excess, and impaired glucose tolerance at 14.3 years of age. Patient 4 had prepubertal overgrowth that evolved into pseudo-acromegaly, insulin resistance, secondary amenorrhea, and androgen excess at 15.6 years. Conclusions: Intractable prepubertal obesity was recognized to culminate in early childhood pseudo-Cushing's syndrome or pseudo-acromegaly, which are manifestations of insulin-resistant hyperinsulinism, and to herald adolescent PCOS.
KW - Insulin resistance
KW - Obesity
KW - Polycystic ovary syndrome
KW - Precocious puberty
KW - Pseudo-acromegaly
KW - Pseudo-Cushing's syndrome
UR - http://www.scopus.com/inward/record.url?scp=33947505766&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33947505766&partnerID=8YFLogxK
M3 - Article
C2 - 17315528
AN - SCOPUS:33947505766
VL - 20
SP - 41
EP - 51
JO - Journal of Pediatric Endocrinology and Metabolism
JF - Journal of Pediatric Endocrinology and Metabolism
SN - 0334-018X
IS - 1
ER -