Intractable early childhood obesity as the initial sign of insulin resistant hyperinsulinism and precursor of polycystic ovary syndrome

Elizabeth E. Littlejohn, Roy E Weiss, Dianne Deplewski, Deborah V. Edidin, Robert Rosenfield

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective: We report that intractable early childhood obesity may be associated with severe insulin resistance syndromes (pseudo-Cushing's syndrome and pseudo-acromegaly) and precede polycystic ovary syndrome (PCOS). Study design/Results: Patient 1 had prepubertal obesity followed by early puberty and was diagnosed with pseudo-Cushing's syndrome and insulin resistance at 10.3 years. Oligomenorrhea, androgen excess, and type 2 diabetes mellitus (DM2) emerged at 13.5 years. Patient 2 developed intractable prepubertal obesity followed by atypical true sexual precocity and pseudo-Cushing's syndrome in early childhood. By 11.3 years, oligomenorrhea, androgen excess, and DM2 had appeared. Patient 3 had prepubertal overgrowth in weight and height and was diagnosed with pseudo-acromegaly, menstrual irregularity, androgen excess, and impaired glucose tolerance at 14.3 years of age. Patient 4 had prepubertal overgrowth that evolved into pseudo-acromegaly, insulin resistance, secondary amenorrhea, and androgen excess at 15.6 years. Conclusions: Intractable prepubertal obesity was recognized to culminate in early childhood pseudo-Cushing's syndrome or pseudo-acromegaly, which are manifestations of insulin-resistant hyperinsulinism, and to herald adolescent PCOS.

Original languageEnglish (US)
Pages (from-to)41-51
Number of pages11
JournalJournal of Pediatric Endocrinology and Metabolism
Volume20
Issue number1
StatePublished - Jan 2007
Externally publishedYes

Fingerprint

Acromegaly
Cushing Syndrome
Polycystic Ovary Syndrome
Pediatric Obesity
Hyperinsulinism
Androgens
Oligomenorrhea
Insulin
Insulin Resistance
Obesity
Glucose Intolerance
Amenorrhea
Puberty
Type 2 Diabetes Mellitus
Weights and Measures

Keywords

  • Insulin resistance
  • Obesity
  • Polycystic ovary syndrome
  • Precocious puberty
  • Pseudo-acromegaly
  • Pseudo-Cushing's syndrome

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health

Cite this

Intractable early childhood obesity as the initial sign of insulin resistant hyperinsulinism and precursor of polycystic ovary syndrome. / Littlejohn, Elizabeth E.; Weiss, Roy E; Deplewski, Dianne; Edidin, Deborah V.; Rosenfield, Robert.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 20, No. 1, 01.2007, p. 41-51.

Research output: Contribution to journalArticle

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