Intracranial space, brain, and cerebrospinal fluid volume measurements obtained with the aid of three-dimensional computerized tomographyin patients with and without Crouzon syndrome

Samir Mardini, Lai Chu See, Lun Jou Lo, Christopher Salgado, Yu Ray Chen

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Object. The authors attempt to provide a standard for volumes of the intracranial space, brain, and cerebrospinal fluid (CSF) in healthy control individuals by using in vivo three-dimensional (3D) computerized tomography (CT) data and to compare these data with those obtained from a group with Crouzon syndrome. Methods. Fifty-seven individuals underwent 3D head CT scanning for nonintracranial-related disease to produce a set of normal volumes for the intracranial space, brain, and CSF. Prediction limits of 95% were obtained to provide a range of acceptable volumes throughout the growing period and early adulthood. Eleven patients (seven boys and four girls, age range 2.2 months-13.4 years) with Crouzon syndrome underwent identical measurements, which were compared with those of the control patients. The control group comprised 35 boys and 22 girls who ranged in age from 0.26 months to 24.4 years. Intracranial space and brain volume showed a progressive increase with age, with three different slopes from birth to adulthood. Male patients were found to have larger volumes than female patients in the same age group. Volume patterns for CSF were not significantly different within a given age or sex. Six patients with Crouzon syndrome had intracranial and brain volumes within the 95% prediction limit, three patients measured above the limit, and two measured below. Conclusions. A standard for volumes of intracranial space and structures provides a guideline for the evaluation of patients with intracranial disease. Volumes in patients with Crouzon syndrome can be matched to their normal age- and sex-matched counterparts.

Original languageEnglish
Pages (from-to)238-246
Number of pages9
JournalJournal of Neurosurgery
Volume103 PEDIATRICS
Issue numberSUPPL. 3
StatePublished - Sep 1 2005
Externally publishedYes

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Craniofacial Dysostosis
Cerebrospinal Fluid
Brain
Tomography
Age Groups
Head
Parturition
Guidelines
Control Groups

Keywords

  • Computerized tomography
  • Crouzon syndrome
  • Pediatric neurosurgery
  • Volume measurement

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Intracranial space, brain, and cerebrospinal fluid volume measurements obtained with the aid of three-dimensional computerized tomographyin patients with and without Crouzon syndrome. / Mardini, Samir; See, Lai Chu; Lo, Lun Jou; Salgado, Christopher; Chen, Yu Ray.

In: Journal of Neurosurgery, Vol. 103 PEDIATRICS, No. SUPPL. 3, 01.09.2005, p. 238-246.

Research output: Contribution to journalArticle

Mardini, Samir ; See, Lai Chu ; Lo, Lun Jou ; Salgado, Christopher ; Chen, Yu Ray. / Intracranial space, brain, and cerebrospinal fluid volume measurements obtained with the aid of three-dimensional computerized tomographyin patients with and without Crouzon syndrome. In: Journal of Neurosurgery. 2005 ; Vol. 103 PEDIATRICS, No. SUPPL. 3. pp. 238-246.
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