Intracranial arterial dolichoectasia

Victor J. Del Brutto, Jorge G. Ortiz, José Biller

Research output: Contribution to journalShort surveypeer-review

32 Scopus citations

Abstract

An increased diameter (ectasis) and/or long and tortuous course (dolichosis) of at least one cerebral artery define intracranial arterial dolichoectasia (IADE). IADE could be detected incidentally or may give rise to an array of neurological complications including ischemic stroke, intracranial hemorrhage, or compression of surrounding neural structures. The basilar artery is preferentially affected and has been studied in more detail, mainly due to the presence of accepted diagnostic criteria proposed by Smoker and colleagues in 1986 (1). Criteria for the diagnoses of dolichoectasia in other cerebral arteries have been suggested. However, they lack validation across studies. The prevalence of IADE is approximately 0.08-6.5% in the general population, while in patients with stroke, the prevalence ranges from 3 to 17%. Variations among case series depend on the characteristics of the studied population, diagnostic tests used, and diagnostic criteria applied. In rare instances, an underlying hereditary condition, connective tissue disorder, or infection predispose to the development of IADE. However, most cases are sporadic and associated with traditional vascular risk factors including advanced age, male gender, and arterial hypertension. The link between this dilative arteriopathy and other vascular abnormalities, such as abdominal aortic aneurysm, coronary artery ectasia, and cerebral small vessel disease, suggests the underlying diffuse vascular process. Further understanding is needed on the physiopathology of IADE and how to prevent its progression and clinical complications.

Original languageEnglish (US)
Article number344
JournalFrontiers in Neurology
Volume8
Issue numberJUL
DOIs
StatePublished - Jul 17 2017
Externally publishedYes

Keywords

  • Dilatative arteriopathy
  • Dolichoectasia
  • Dolichosis
  • Ectasia
  • Intracranial arterial dolichoectasia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Intracranial arterial dolichoectasia'. Together they form a unique fingerprint.

Cite this