Intracerebral hemorrhage in a primate model: Effect on regional cerebral blood flow

Ross Bullock; John Brock-Utne; James van Dellen; Gordon Blake

doi:10.1016/0090-3019(88)90065-1

Intracerebral hemorrhage in a primate model: Effect on regional cerebral blood flow

Ross Bullock, John Brock-Utne, James van Dellen, Gordon Blake

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

The dynamic changes in regional cerebral blood flow (rCBF), induced by a developing intracerebral hematoma, were studied in eight anesthetized monkeys. Hematomas were generated by allowing femoral arterial blood to enter the caudate nucleus via a stereotactically implanted needle. Intracranial pressure peaked at 51 ± 8 mmHg at 3 minutes after the ictus, and remained high throughout the 3-hour procedure. Cerebral blood flow was significantly reduced in all brain regions for 1 hour after the ictus. The lowest rCBF values were recorded in the immediate clot penumbra and were below threshold levels for ischemic neuronal damage for 90 minutes after the hemorrhage.

Original language	English (US)
Pages (from-to)	101-107
Number of pages	7
Journal	Surgical neurology
Volume	29
Issue number	2
DOIs	https://doi.org/10.1016/0090-3019(88)90065-1
State	Published - Feb 1988

Keywords

Intracerebral hematoma
Primates
Raised intracranial pressure
Regional cerebral blood flow

ASJC Scopus subject areas

Clinical Neurology
Surgery

Access to Document

10.1016/0090-3019(88)90065-1

Cite this

@article{388c05475bc04d62a9ab53c3024d9c9b,

title = "Intracerebral hemorrhage in a primate model: Effect on regional cerebral blood flow",

abstract = "The dynamic changes in regional cerebral blood flow (rCBF), induced by a developing intracerebral hematoma, were studied in eight anesthetized monkeys. Hematomas were generated by allowing femoral arterial blood to enter the caudate nucleus via a stereotactically implanted needle. Intracranial pressure peaked at 51 ± 8 mmHg at 3 minutes after the ictus, and remained high throughout the 3-hour procedure. Cerebral blood flow was significantly reduced in all brain regions for 1 hour after the ictus. The lowest rCBF values were recorded in the immediate clot penumbra and were below threshold levels for ischemic neuronal damage for 90 minutes after the hemorrhage.",

keywords = "Intracerebral hematoma, Primates, Raised intracranial pressure, Regional cerebral blood flow",

author = "Ross Bullock and John Brock-Utne and {van Dellen}, James and Gordon Blake",

note = "Funding Information: This work was supported, in part, by a grant from Bayer AG, Federal Republic of Germany, and by a Natal University research gram .",

year = "1988",

month = feb,

doi = "10.1016/0090-3019(88)90065-1",

language = "English (US)",

volume = "29",

pages = "101--107",

journal = "World Neurosurgery",

issn = "1878-8750",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Intracerebral hemorrhage in a primate model

T2 - Effect on regional cerebral blood flow

AU - Bullock, Ross

AU - Brock-Utne, John

AU - van Dellen, James

AU - Blake, Gordon

N1 - Funding Information: This work was supported, in part, by a grant from Bayer AG, Federal Republic of Germany, and by a Natal University research gram .

PY - 1988/2

Y1 - 1988/2

N2 - The dynamic changes in regional cerebral blood flow (rCBF), induced by a developing intracerebral hematoma, were studied in eight anesthetized monkeys. Hematomas were generated by allowing femoral arterial blood to enter the caudate nucleus via a stereotactically implanted needle. Intracranial pressure peaked at 51 ± 8 mmHg at 3 minutes after the ictus, and remained high throughout the 3-hour procedure. Cerebral blood flow was significantly reduced in all brain regions for 1 hour after the ictus. The lowest rCBF values were recorded in the immediate clot penumbra and were below threshold levels for ischemic neuronal damage for 90 minutes after the hemorrhage.

AB - The dynamic changes in regional cerebral blood flow (rCBF), induced by a developing intracerebral hematoma, were studied in eight anesthetized monkeys. Hematomas were generated by allowing femoral arterial blood to enter the caudate nucleus via a stereotactically implanted needle. Intracranial pressure peaked at 51 ± 8 mmHg at 3 minutes after the ictus, and remained high throughout the 3-hour procedure. Cerebral blood flow was significantly reduced in all brain regions for 1 hour after the ictus. The lowest rCBF values were recorded in the immediate clot penumbra and were below threshold levels for ischemic neuronal damage for 90 minutes after the hemorrhage.

KW - Intracerebral hematoma

KW - Primates

KW - Raised intracranial pressure

KW - Regional cerebral blood flow

UR - http://www.scopus.com/inward/record.url?scp=0023903529&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023903529&partnerID=8YFLogxK

U2 - 10.1016/0090-3019(88)90065-1

DO - 10.1016/0090-3019(88)90065-1

M3 - Article

C2 - 3336844

AN - SCOPUS:0023903529

VL - 29

SP - 101

EP - 107

JO - World Neurosurgery

JF - World Neurosurgery

SN - 1878-8750

IS - 2

ER -

Intracerebral hemorrhage in a primate model: Effect on regional cerebral blood flow

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this