Intracerebral hemorrhage in a primate model: Effect on regional cerebral blood flow

Ross Bullock, John Brock-Utne, James van Dellen, Gordon Blake

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


The dynamic changes in regional cerebral blood flow (rCBF), induced by a developing intracerebral hematoma, were studied in eight anesthetized monkeys. Hematomas were generated by allowing femoral arterial blood to enter the caudate nucleus via a stereotactically implanted needle. Intracranial pressure peaked at 51 ± 8 mmHg at 3 minutes after the ictus, and remained high throughout the 3-hour procedure. Cerebral blood flow was significantly reduced in all brain regions for 1 hour after the ictus. The lowest rCBF values were recorded in the immediate clot penumbra and were below threshold levels for ischemic neuronal damage for 90 minutes after the hemorrhage.

Original languageEnglish (US)
Pages (from-to)101-107
Number of pages7
JournalSurgical neurology
Issue number2
StatePublished - Feb 1988


  • Intracerebral hematoma
  • Primates
  • Raised intracranial pressure
  • Regional cerebral blood flow

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery


Dive into the research topics of 'Intracerebral hemorrhage in a primate model: Effect on regional cerebral blood flow'. Together they form a unique fingerprint.

Cite this