Intracerebral hemorrhage in a primate model: Effect on regional cerebral blood flow

Ross Bullock; John Brock-Utne; James van Dellen; Gordon Blake

doi:10.1016/0090-3019(88)90065-1

Intracerebral hemorrhage in a primate model: Effect on regional cerebral blood flow

Ross Bullock, John Brock-Utne, James van Dellen, Gordon Blake

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

The dynamic changes in regional cerebral blood flow (rCBF), induced by a developing intracerebral hematoma, were studied in eight anesthetized monkeys. Hematomas were generated by allowing femoral arterial blood to enter the caudate nucleus via a stereotactically implanted needle. Intracranial pressure peaked at 51 ± 8 mmHg at 3 minutes after the ictus, and remained high throughout the 3-hour procedure. Cerebral blood flow was significantly reduced in all brain regions for 1 hour after the ictus. The lowest rCBF values were recorded in the immediate clot penumbra and were below threshold levels for ischemic neuronal damage for 90 minutes after the hemorrhage.

Original language	English (US)
Pages (from-to)	101-107
Number of pages	7
Journal	Surgical neurology
Volume	29
Issue number	2
DOIs	https://doi.org/10.1016/0090-3019(88)90065-1
State	Published - Feb 1988

Keywords

Intracerebral hematoma
Primates
Raised intracranial pressure
Regional cerebral blood flow

ASJC Scopus subject areas

Clinical Neurology
Surgery

Access to Document

10.1016/0090-3019(88)90065-1

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title = "Intracerebral hemorrhage in a primate model: Effect on regional cerebral blood flow",

abstract = "The dynamic changes in regional cerebral blood flow (rCBF), induced by a developing intracerebral hematoma, were studied in eight anesthetized monkeys. Hematomas were generated by allowing femoral arterial blood to enter the caudate nucleus via a stereotactically implanted needle. Intracranial pressure peaked at 51 ± 8 mmHg at 3 minutes after the ictus, and remained high throughout the 3-hour procedure. Cerebral blood flow was significantly reduced in all brain regions for 1 hour after the ictus. The lowest rCBF values were recorded in the immediate clot penumbra and were below threshold levels for ischemic neuronal damage for 90 minutes after the hemorrhage.",

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