Intracellular starvation in the insulin resistance syndrome and type II diabetes mellitus

A. M. Fournier

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Statistical associations of insulin resistance, type II diabetes, hypertension and hyperlipidemia have been well documented, but the pathophysiology of the 'insulin resistance syndrome' is unknown. This article explores the hypothesis that intracellular starvation plays a central role in the development of type II diabetes, hypertension and hyperlipidemia. According to this hypothesis, insulin resistance leads to inadequate intracellular glucose, which in turn leads to insufficient amounts of adenosine triphosphate needed for ion transfer, and to drive energy-requiring reactions. Indirect evidence supporting this hypothesis is presented. Intracellular starvation is also discussed as an alternative to the 'glucose hypothesis' to explain certain complications of diabetes.

Original languageEnglish
Pages (from-to)95-99
Number of pages5
JournalMedical Hypotheses
Volume51
Issue number2
StatePublished - Aug 1 1998
Externally publishedYes

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Starvation
Type 2 Diabetes Mellitus
Insulin Resistance
Hyperlipidemias
Hypertension
Glucose
Diabetes Complications
Adenosine Triphosphate
Ions

ASJC Scopus subject areas

  • Developmental Biology
  • Medicine(all)
  • Drug Discovery

Cite this

Intracellular starvation in the insulin resistance syndrome and type II diabetes mellitus. / Fournier, A. M.

In: Medical Hypotheses, Vol. 51, No. 2, 01.08.1998, p. 95-99.

Research output: Contribution to journalArticle

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