Intracellular bacterial communities of uropathogenic Escherichia coli in urinary tract pathogenesis

Gregory G. Anderson, Karen W. Dodson, Thomas M. Hooton, Scott J. Hultgren

Research output: Contribution to journalReview article

118 Scopus citations

Abstract

Urinary tract infections in young, healthy women frequently recur, despite their traditional classification as acute infections. Conventional wisdom dictates that uropathogens causing recurrent infections in such individuals come from the fecal or vaginal flora, in the same manner as the initial infection. However, recent studies of uropathogenic Escherichia coli have found that it can carry out a complex developmental program within the superficial epithelial cells of the mouse bladder, forming intracellular bacterial communities with many biofilm-like properties. These intracellular biofilms allow the bacteria to outlast a strong host immune response to establish a dormant reservoir of pathogens inside the bladder cells. Re-emergence of bacteria from this reservoir might be the source of recurrent infection.

Original languageEnglish (US)
Pages (from-to)424-430
Number of pages7
JournalTrends in Microbiology
Volume12
Issue number9
DOIs
StatePublished - Sep 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

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