Intracarotid VP-16 in malignant brain tumors

Lynn G Feun, YaYen Lee, Wai Kwan Alfred Yung, Niramol Savaraj, Sidney Wallace

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Twenty-eight patients with malignant brain tumors (16 with primary brain tumors and 12 with brain metastases) progressing after cranial irradiation with or without chemotherapy received varying doses of intracarotid VP-16. Courses of therapy were repeated every 4 weeks along with computerized axial tomography scan and neurologic examination. Of 15 evaluable patients with primary malignant brain tumors, 1 responded to therapy and 5 had no immediate tumor progression for 2-10 months. None of 12 evaluable patients with brain metastases responded to intracarotid VP-16 although 5 had no immediate tumor progression from 1-4 months. Side effects of treatment were uncommon. Using this route of administration, intracarotid VP-16 does not appear to increase response rates in patients with primary malignant brain tumors, compared with results reported for intravenous VP-16.

Original languageEnglish
Pages (from-to)397-401
Number of pages5
JournalJournal of Neuro-Oncology
Volume4
Issue number4
DOIs
StatePublished - Dec 1 1987

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Etoposide
Brain Neoplasms
Neoplasm Metastasis
Cranial Irradiation
Neurologic Examination
Brain
Neoplasms
Therapeutics
Tomography
Drug Therapy

Keywords

  • brain tumors
  • intracarotid
  • VP-16

ASJC Scopus subject areas

  • Neuroscience(all)
  • Oncology
  • Clinical Neurology
  • Cancer Research

Cite this

Intracarotid VP-16 in malignant brain tumors. / Feun, Lynn G; Lee, YaYen; Yung, Wai Kwan Alfred; Savaraj, Niramol; Wallace, Sidney.

In: Journal of Neuro-Oncology, Vol. 4, No. 4, 01.12.1987, p. 397-401.

Research output: Contribution to journalArticle

Feun, Lynn G ; Lee, YaYen ; Yung, Wai Kwan Alfred ; Savaraj, Niramol ; Wallace, Sidney. / Intracarotid VP-16 in malignant brain tumors. In: Journal of Neuro-Oncology. 1987 ; Vol. 4, No. 4. pp. 397-401.
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